Evidence map›Paper›PMID 27007381›Full record

ReviewMarine drugs2016

Integrated (Meta) Genomic and Synthetic Biology Approaches to Develop New Biocatalysts.

María L Parages, José A Gutiérrez-Barranquero, F Jerry Reen, Alan D W Dobson, Fergal O'Gara

Abstract readReview
In one paragraph

Review in Marine drugs, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Screening Strategies for Biosurfactant Discovery.Advances in biochemical engineering/biotechnology · 2022
    Article
  4. Article
  5. Harnessing the sponge microbiome for industrial biocatalysts.Applied microbiology and biotechnology · 2020
    Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

María L ParagesBIOMERIT Research Centre, School of Microbiology, University College Cork, National University of Ireland, Cork, Ireland. maria.lopezparages@ucc.ie.
José A Gutiérrez-BarranqueroBIOMERIT Research Centre, School of Microbiology, University College Cork, National University of Ireland, Cork, Ireland. jgutierrez@ucc.ie.
F Jerry ReenBIOMERIT Research Centre, School of Microbiology, University College Cork, National University of Ireland, Cork, Ireland. J.Reen@ucc.ie.
Alan D W DobsonSchool of Microbiology, University College Cork, Cork, Ireland. a.dobson@ucc.ie.
Fergal O'GaraBIOMERIT Research Centre, School of Microbiology, University College Cork, National University of Ireland, Cork, Ireland. f.ogara@ucc.ie.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, the marine environment has been the subject of increasing attention from biotechnological and pharmaceutical industries as a valuable and promising source of novel bioactive compounds. Marine biodiscovery programmes have begun to reveal the extent of novel compounds encoded within the enormous bacterial richness and diversity of the marine ecosystem. A combination of unique physicochemical properties and spatial niche-specific substrates, in wide-ranging and extreme habitats, underscores the potential of the marine environment to deliver on functionally novel biocatalytic activities. With the growing need for green alternatives to industrial processes, and the unique transformations which nature is capable of performing, marine biocatalysts have the potential to markedly improve current industrial pipelines. Furthermore, biocatalysts are known to possess chiral selectivity and specificity, a key focus of pharmaceutical drug design. In this review, we discuss how the explosion in genomics based sequence analysis, allied with parallel developments in synthetic and molecular biology, have the potential to fast-track the discovery and subsequent improvement of a new generation of marine biocatalysts.

Indexed as

Drug DesignAnimalsAquatic OrganismsBiocatalysisBiodiversityBiological ProductsBiotechnologyDrug DiscoveryHumansMetagenomicsMolecular BiologySynthetic BiologyBiological Productsbiocatalysisbiodiscoverychassisheterologous expressionmarinemetagenomicssynthetic biologyvector

Identifiers

PMID27007381
PMCPMC4810074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.