ArticlePLoS pathogens2016
Activation of Plant Innate Immunity by Extracellular High Mobility Group Box 3 and Its Inhibition by Salicylic Acid.
Article in PLoS pathogens, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 94 citations in OpenAlex.
- Genome-Wide Identification and Expression Analysis of theInternational journal of molecular sciences · 2025Article
- Genome-Wide Identification and Expression Analysis of theInternational journal of molecular sciences · 2024Article
- Recognition of nonself is necessary to activate Drosophila's immune response against an insect parasite.BMC biology · 2024Article
- Macrophage-derived exosomal HMGB3 regulates silica-induced pulmonary inflammation by promoting M1 macrophage polarization and recruitment.Particle and fibre toxicology · 2024Article
- Metabolic Responses of the MicroalgaInternational journal of molecular sciences · 2023Article
- Secondary metabolites related to the resistance ofHeliyon · 2023Article
- Ambivalent response in pathogen defense: A double-edged sword?Plant communications · 2022Review
- Salicylic Acid in Root Growth and Development.International journal of molecular sciences · 2022Review
- An Anecdote on Prospective Protein Targets for Developing Novel Plant Growth Regulators.Molecular biotechnology · 2022Review
- HMGB1-Like Dorsal Switch Protein 1 Triggers a Damage Signal in Mosquito Gut to Activate Dual Oxidase via Eicosanoids.Journal of innate immunity · 2022Article
- Activation of plant immunity by exposure to dinitrogen pentoxide gas generated from air using plasma technology.PloS one · 2022Article
- Dorsal switch protein 1 as a damage signal in insect gut immunity to activate dual oxidaseFrontiers in immunology · 2022Article
- Identification of resistance gene analogs of the NBS-LRR family through transcriptome probing andFrontiers in genetics · 2022Article
- Signaling Pathways and Downstream Effectors of Host Innate Immunity in Plants.International journal of molecular sciences · 2021Review
- Overexpression of OsHMGB707, a High Mobility Group Protein, Enhances Rice Drought Tolerance by Promoting Stress-Related Gene Expression.Frontiers in plant science · 2021Article
- Deciphering the Binding of Salicylic Acid toInternational journal of molecular sciences · 2020Article
- In Vitro Analytical Approaches to Study Plant Ligand-Receptor Interactions.Plant physiology · 2020Review
- Perception of Damaged Self in Plants.Plant physiology · 2020Review
- ARABIDOPSIS DEHISCENCE ZONE POLYGALACTURONASE 1 (ADPG1) releases latent defense signals in stems with reduced lignin content.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Salicylic Acid Targets Protein Phosphatase 2A to Attenuate Growth in Plants.Current biology : CB · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Damage-associated molecular pattern molecules (DAMPs) signal the presence of tissue damage to induce immune responses in plants and animals. Here, we report that High Mobility Group Box 3 (HMGB3) is a novel plant DAMP. Extracellular HMGB3, through receptor-like kinases BAK1 and BKK1, induced hallmark innate immune responses, including i) MAPK activation, ii) defense-related gene expression, iii) callose deposition, and iv) enhanced resistance to Botrytis cinerea. Infection by necrotrophic B. cinerea released HMGB3 into the extracellular space (apoplast). Silencing HMGBs enhanced susceptibility to B. cinerea, while HMGB3 injection into apoplast restored resistance. Like its human counterpart, HMGB3 binds salicylic acid (SA), which results in inhibition of its DAMP activity. An SA-binding site mutant of HMGB3 retained its DAMP activity, which was no longer inhibited by SA, consistent with its reduced SA-binding activity. These results provide cross-kingdom evidence that HMGB proteins function as DAMPs and that SA is their conserved inhibitor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.