ArticleJournal of magnetic resonance imaging : JMRI2016
Quantification of renal steatosis in type II diabetes mellitus using dixon-based MRI.
Article in Journal of magnetic resonance imaging : JMRI, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Renal fat fraction quantified by MRI-Dixon predicts the renal function progression in patients with type 2 diabetes mellitus: a prospective cohort study.Journal of endocrinological investigation · 2026Article
- Association of hepatic steatosis with MRI-defined renal steatosis in type 2 diabetes: a cross-sectional imaging and clinical modeling study.Frontiers in nutrition · 2026Article
- Quantitative assessment of renal and perirenal adipose tissue distribution at 5 T: a feasibility study.BMC medical imaging · 2025Article
- Magnetic resonance imaging for noninvasive assessment of renal fat deposition and hypoxia in diabetic kidney disease.BMC medical imaging · 2025Article
- Renal Fat Accumulation Assessed by MRI or CT and Its Association with Clinical and Metabolic Disorders: A Systematic Imaging Review.Journal of clinical medicine · 2025Review
- Renal ectopic fat deposition and hemodynamics in type 2 diabetes mellitus assessment with magnetic resonance imaging.Insights into imaging · 2025Article
- Is fat quantification based on proton density fat fraction useful for differentiating renal tumor types?Abdominal radiology (New York) · 2025Article
- Is fat quantification based on proton density fat fraction useful for differentiating renal tumor types?Abdominal radiology (New York) · 2025Article
- Quantitative assessment of renal steatosis in patients with type 2 diabetes mellitus using the iterative decomposition of water and fat with echo asymmetry and least squares estimation quantification sequence imaging: repeatability and clinical implications.Quantitative imaging in medicine and surgery · 2024Article
- Three-dimensional convolutional neural network-based classification of chronic kidney disease severity using kidney MRI.Scientific reports · 2024Article
- Correlation between circulating advanced glycation end products and thioredoxin-interacting protein levels and renal fat content in type 2 diabetes mellitus patients.Diabetology & metabolic syndrome · 2024Article
- Magnetic Resonance Imaging in Clinical Trials of Diabetic Kidney Disease.Journal of clinical medicine · 2023Review
- Renal ectopic lipid deposition in rats with early-stage diabetic nephropathy evaluated by the MR mDixon-Quant technique: association with the expression of SREBP-1 and PPARα in renal tissue.Quantitative imaging in medicine and surgery · 2023Article
- Increased renal uptake and urine excretion of oxidized LDL is possibly associated with formation of large calcium oxalate nephrolithiasis: a preliminary study.World journal of urology · 2023Article
- mDIXON-Quant for differentiation of renal damage degree in patients with chronic kidney disease.Frontiers in endocrinology · 2023Article
- An update on the role of thioredoxin-interacting protein in diabetic kidney disease: A mini review.Frontiers in medicine · 2023Review
- The utility of texture analysis of kidney MRI for evaluating renal dysfunction with multiclass classification model.Scientific reports · 2022Article
- New insights into the role of empagliflozin on diabetic renal tubular lipid accumulation.Diabetology & metabolic syndrome · 2022Article
- Renal fat fraction is significantly associated with the risk of chronic kidney disease in patients with type 2 diabetes.Frontiers in endocrinology · 2022Article
- Renal Lipid Metabolism Abnormalities in Obesity and Clear Cell Renal Cell Carcinoma.Metabolites · 2021Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo evaluate renal lipid content in subjects with and without type II diabetes mellitus (DM2) using Dixon-based magnetic resonance imaging (MRI). MATERIALS AND
methodsThis retrospective study was approved by the Institutional Review Board and compliant with the Health Insurance Portability and Accountability Act. Sixty-nine adults with or without DM2 (n = 29, n = 40) underwent 3T MRI of the abdomen using 3D multiecho Dixon gradient-echo acquisition and proton-density fat fraction (FF) reconstruction. FF values were recorded within segmented regions of interest in the kidneys and liver. The FF measurement error was estimated from the within-subject difference between the right and left kidneys using Bland-Altman analysis. Correlation between renal FF, hepatic FF, and body mass index (BMI) was evaluated. The association between renal FF and DM2 was evaluated by Wilcoxon rank sum test as well as by multivariate regression to correct for potential confounding effects of age, sex, BMI, creatinine, and hepatic FF. P < 0.05 was considered statistically significant.
resultsPer-subject 95% limits of agreement of the renal FF measurement were [-3.26%, +3.22%]. BMI was significantly correlated with renal FF (r = 0.266, P = 0.027) and with liver FF (r = 0.344, P = 0.006). Correlation between renal and hepatic FF did not reach statistical significance (r = 0.215, P = 0.090). Median renal FF (±interquartile range) was 2.18% (±2.52%) in the DM2 cohort, significantly higher than 0.80% (±2.63%) in the non-DM2 cohort (P < 0.001). After correcting for potential confounders, the relationship between DM2 and renal FF remained statistically significant (P = 0.005).
conclusionRenal lipid content can be measured noninvasively using Dixon-based MRI and may be increased in subjects with DM2 compared to those without DM2. J. Magn. Reson. Imaging 2016;44:1312-1319.
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