ArticleDigestive diseases and sciences2016
Association Between Fecal Calprotectin Levels and Small-bowel Inflammation Score in Capsule Endoscopy: A Multicenter Retrospective Study.
Article in Digestive diseases and sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- A novel PillCam Crohn's capsule score (Eliakim score) for quantification of mucosal inflammation in Crohn's disease.United European gastroenterology journal · 2020Trial
- Capsule Endoscopy in Inflammatory Bowel Disease: Current Status and Issues in Clinical Practice.DEN open · 2026Review
- Fecal Calprotectin and Segmental Inflammation in Small Bowel Crohn's Disease: A Capsule Endoscopy-Based Study.Biomedicines · 2025Article
- Effectiveness of biologics for endoscopic healing in patients with isolated proximal small bowel Crohn's disease.World journal of gastroenterology · 2025Article
- Clinical value of fecal calprotectin for evaluating disease activity in patients with Crohn's disease.Frontiers in physiology · 2023Article
- Predictive Markers of Crohn's Disease in Small Bowel Capsule Endoscopy: A Retrospective Study of Small Bowel Capsule Endoscopy.Journal of clinical medicine · 2022Article
- Is the Mixed Use of Magnetic Resonance Enterography and Computed Tomography Enterography Adequate for Routine Periodic Follow-Up of Bowel Inflammation in Patients with Crohn's Disease?Korean journal of radiology · 2022Article
- Assessment of a new score for capsule endoscopy in pediatric Crohn's disease (CE-CD).Endoscopy international open · 2021Article
- Flattening in the Anteroposterior Direction of the Terminal Ileum or Sigmoid Colon Lying Across the Psoas Muscle on Magnetic Resonance Enterography in Patients with Crohn's Disease.Korean journal of radiology · 2021Article
- Proteomic Evaluation of the Acute Radiation Syndrome of the Gastrointestinal Tract in a Murine Total-body Irradiation Model.Health physics · 2019Article
- Validity of Capsule Endoscopy in Monitoring Therapeutic Interventions in Patients with Crohn's Disease.Journal of clinical medicine · 2018Article
- Unsuspected Small-Bowel Crohn's Disease in Elderly Patients Diagnosed by Video Capsule Endoscopy.Diagnostic and therapeutic endoscopy · 2018Article
- Endoscopic evaluation in diagnosis and management of inflammatory bowel disease.World journal of gastrointestinal endoscopy · 2016Review
- Does Gastric Surgery (Such as Bariatric Surgery) Impact the Risk of Intestinal Inflammation?Inflammatory intestinal diseases · 2016Review
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Authors and funding
15 authors at 9 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccurate inflammation reporting in capsule endoscopy (CE) is important for diagnosis and monitoring of treatment of inflammatory bowel disease (IBD). Fecal calprotectin (FC) is a highly specific biomarker of gut inflammation. Lewis score (LS) was developed to standardize quantification of inflammation in small-bowel (SB) CE images. GOALS: Multicenter retrospective study aiming to investigate correlation between LS and FC in a large group of patients undergoing CE for suspected or known small-bowel IBD, and to develop a model for prediction of CE results (LS) based on FC levels. STUDY: Five academic centers and a district general hospital offering CE in UK, Finland, Sweden, Canada, and Israel. In total, 333 patients were recruited. They had small-bowel CE and FC done within 3 months.
resultsOverall, correlation between FC and LS was weak (r s: 0.232, P < 0.001). When two clinically significant FC thresholds (100 and 250 μg/g) were examined, the r s between FC and LS was 0.247 (weak) and 0.337 (moderate), respectively (P = 0.307). For clinically significant (LS ≥ 135) or negative (LS < 135) for SB inflammation, ROC curves gave an optimum cutoff point of FC 76 μg/g with sensitivity 0.59 and specificity 0.41. LIMITATIONS: Retrospective design.
conclusionsLS appears to show low correlation with FC as well as other serology markers of inflammation. FC does not appear to be a reliable biomarker for significant small-bowel inflammation. Nevertheless, FC level ≥ 76 μg/g may be associated with appreciable visual inflammation on small-bowel CE in patients with negative prior diagnostic workup.
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