Evidence map›Paper›PMID 27007134›Full record

ArticleDigestive diseases and sciences2016

Moderate Alcohol Use and Insulin Action in Chronic Hepatitis C Infection.

Blaire E Burman, Peter Bacchetti, Mandana Khalili

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive diseases and sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01858012 (Impact of Hepatitis C on Insulin Sensitivity and Insulin Secretion in Latinos), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01858012 active not recruitingnot on this map

Impact of Hepatitis C on Insulin Sensitivity and Insulin Secretion in Latinos

TypeobservationalSponsorUniversity of California, San FranciscoRan2008 to 2026Enrolled250ConditionsInsulin ResistanceArmsModerate alcohol cessation
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Blaire E BurmanDepartment of Medicine, San Francisco General Hospital, University of California, San Francisco, 1001 Potrero Avenue, NH-3D, San Francisco, CA, 94110, USA.
Peter BacchettiDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Mandana KhaliliDepartment of Medicine, San Francisco General Hospital, University of California, San Francisco, 1001 Potrero Avenue, NH-3D, San Francisco, CA, 94110, USA. Mandana.khalili@ucsf.edu.
University of California, San Francisco · USSan Francisco General Hospital · US

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Irfan J Lodhi · 2013 to 2026
$27.1M
NRSA Hepatology Training GrantT32DK060414 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mandana Khalili, JACQUELYN J. MAHER · 2002 to 2026
$6.8M
Impact of Hepatitis C on Insulin Sensitivity and Insulin Secretion in LatinosR01DK074673 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHALILI, MANDANA · 2008 to 2012
$2.2M
Mentoring Multidisciplinary Patient-Oriented Research in Viral HepatitisK24AA022523 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHALILI, MANDANA · 2013 to 2023
$1.9M
NCATS NIH HHS UL1 TR000004NIAAA NIH HHS K24 AA022523NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK026743NIDDK NIH HHS R01 DK074673NIDDK NIH HHS T32 DK060414
6 · The paper itself

Abstract

BACKGROUND AND

aimChronic hepatitis C (HCV) is associated with metabolic abnormalities including insulin resistance (IR) and diabetes. While moderate alcohol consumption is known to have beneficial metabolic effects in the general population, such potential effects in HCV are unknown. We aimed to assess the association between graded alcohol intake and IR, insulin secretion, and metabolic syndrome in HCV.

methodsNinety-five non-diabetic HCV-infected patients underwent detailed metabolic testing. IR was directly measured via steady-state plasma glucose (SSPG) during a 240-min insulin suppression test. Total insulin secretion and insulinogenic index were determined by 75-g oral glucose tolerance test. Genotyping of CYP2E1 was performed to detect genetic polymorphisms influencing alcohol metabolism.

resultsIn this cohort, 61 % were abstinent from alcohol for the past 12 months, while 22 % were moderate, and 17 % heavy drinkers. Obesity and nonwhite ethnicity were the strongest predictors of IR. Moderate alcohol intake (vs none) was significantly associated with lower SSPG only among those with normal BMI (coef -72.9, 95 % CI -128.1 to -17.6, p = 0.01). Alcohol use was not associated with insulin secretion parameters when controlling for IR and other factors. Heavy alcohol intake (OR 3.2, 95 % CI 0.86-12.3) and nonwhite ethnicity (OR 7.1, 95 % CI 1.5-33.3) were associated with metabolic syndrome. Among nonwhites, the odds of metabolic syndrome were fivefold higher for heavy drinkers.

conclusionsModerate alcohol intake is associated with improved insulin sensitivity in HCV, although this benefit was limited to normal-weight individuals. The potential benefit of moderate alcohol on IR and its metabolic consequences in HCV warrants further longitudinal investigation.

Indexed as

Insulin ResistanceAdultAlcohol DrinkingBlood GlucoseCytochrome P-450 CYP2E1EthnicityFemaleGenotypeGlucose Tolerance TestHepatitis C, ChronicHumansInsulinInsulin SecretionMaleMetabolic SyndromeMiddle AgedBlood GlucoseCytochrome P-450 CYP2E1InsulinClamp testingHepatitis CInsulin resistanceInsulin secretionMetabolic syndrome

Identifiers

PMID27007134
PMCPMC4945365
OpenAlexW2310218030

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.