Evidence map›Paper›PMID 27006966›Full record

ArticleOpen forum infectious diseases2016

Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease.

Jessica Galloway-Peña, Meredith E Clement, Batu K Sharma Kuinkel, Felicia Ruffin, Anthony R Flores, Howard Levinson, Samuel A Shelburne, Zack Moore, Vance G Fowler

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Evaluating the use of whole-genome sequencing and SangerJournal of medical microbiology · 2026
    Article
  2. EmergentInfection and immunity · 2024
    Article
  3. Article
  4. Population Genomics ofmSystems · 2021
    Article
  5. Cryptic prophages within aMicrobial genomics · 2021
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jessica Galloway-PeñaDepartment of Infectious Disease Infection Control and Employee Health , MD Anderson Cancer Center , Houston, Texas.
Meredith E ClementDivision of Infectious Diseases , Duke University Medical Center , Durham, North Carolina.
Batu K Sharma KuinkelDivision of Infectious Diseases , Duke University Medical Center , Durham, North Carolina.
Felicia RuffinDivision of Infectious Diseases , Duke University Medical Center , Durham, North Carolina.
Anthony R FloresSection of Infectious Diseases, Department of Pediatrics , Baylor College of Medicine and Texas Children's Hospital , Houston.
Howard LevinsonDepartments of Surgery, Dermatology, and Pathology , Duke University Medical Center , Durham.
Samuel A ShelburneDepartment of Infectious Disease Infection Control and Employee Health , MD Anderson Cancer Center , Houston, Texas.
Zack MooreNorth Carolina Department of Health and Human Services, Raleigh.
Vance G FowlerDivision of Infectious Diseases , Duke University Medical Center , Durham, North Carolina.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Ruth L. Kirschstein National Research Service Award (NRSA)- T32T32AI007392 · NIAID · DUKE UNIVERSITY · PI Amy Lynn Corneli, Guido Ferrari · 1990 to 2026
$9.8M
Host Susceptibility to S. aureusR01AI068804 · NIAID · DUKE UNIVERSITY · PI FOWLER, VANCE G. · 2007 to 2016
$6.9M
Contribution of catabolite control protein A to group A streptococcal virulenceR01AI089891 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SHELBURNE, SAMUEL A · 2011 to 2015
$1.6M
Mentoring Patient Oriented Research in Antibiotic-Resistant BacteriaK24AI093969 · NIAID · DUKE UNIVERSITY · PI FOWLER, VANCE G. · 2011 to 2020
$1.6M
NCI NIH HHS P30 CA016672NIAID NIH HHS K24 AI093969NIAID NIH HHS R01 AI068804NIAID NIH HHS R01 AI089891NIAID NIH HHS T32 AI007392
6 · The paper itself

Abstract

Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks.

Indexed as

group A Streptococcusinvasive diseasespeBStreptococcuspyogeneswhole-genome sequencing

Identifiers

PMID27006966
PMCPMC4800461

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.