ArticleActa pharmaceutica Sinica. B2016
Sodium humate accelerates cutaneous wound healing by activating TGF-β/Smads signaling pathway in rats.
Article in Acta pharmaceutica Sinica. B, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
- Discrete Microdomain-Bonded Binder Enables Mechanically Robust Micron-Silicon Anodes in Lithium-Ion Batteries.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Sodium Humate Combined with Low-Dose Cefixime Alleviates Intestinal Injury in ETEC Infection via Inhibition of the TLR4/NF-κB Pathway.Biomolecules · 2026Article
- Engineering a Nanostructured Hybrid Gel System with Sodium Humate for Enhanced Wound Healing.Journal of functional biomaterials · 2026Article
- Design, Characterization, and Wound-Healing Evaluation of Sodium Humate Transferosome-Loaded Alginate/HPMC Dermal Patches.Pharmaceutics · 2026Article
- Pharmacological Effects of Humic Substances and Their Signaling Mechanisms.Molecules (Basel, Switzerland) · 2025Review
- Biomedical Applications of Humic Substances: From Natural Biopolymers to Therapeutic Agents.Antioxidants (Basel, Switzerland) · 2025Review
- Neutral Sodium Humate Modulates Growth, Slaughter Traits, Antioxidant Status, and Gut Health in Yellow-Feathered Broilers.Animals : an open access journal from MDPI · 2025Article
- Multifunctional hydrogel targeting senescence to accelerate diabetic wound healing through promoting angiogenesis.Journal of nanobiotechnology · 2025Article
- Dietary Sodium Humate Improves Intestinal Mucosal Immune and Biological Barriers of Genetically Improved Farmed Tilapia (Aquaculture nutrition · 2025Article
- Coal-Derived Humic Substances: Insight into Chemical Structure Parameters and Biomedical Properties.Molecules (Basel, Switzerland) · 2024Article
- Sodium humate ameliorates LPS-induced liver injury in mice by inhibiting TLR4/NF-κB and activating NRF2/HO-1 signaling pathways.Molecular biology reports · 2024Article
- Preparation, characterization, bacteriostatic efficacy, and mechanism of zinc/selenium-loaded sodium humate.Applied microbiology and biotechnology · 2023Article
- Enhanced Antioxidant Activity and Reduced Cytotoxicity of Silver Nanoparticles Stabilized by Different Humic Materials.Polymers · 2023Article
- Advance in topical biomaterials and mechanisms for the intervention of pressure injury.iScience · 2023Review
- Sodium Humate-Derived Gut Microbiota Ameliorates Intestinal Dysfunction Induced byMicrobiology spectrum · 2023Article
- Therapeutic Efficiency of Humic Acids in Intoxications.Life (Basel, Switzerland) · 2023Review
- Influence of Sodium Humate on the Growth Performance, Diarrhea Incidence, Blood Parameters, and Fecal Microflora of Pre-Weaned Dairy Calves.Animals : an open access journal from MDPI · 2022Article
- Humic Acids Inhibit Platelet Activation to Reduce Venous Thromboembolism in Mice.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Sodium Humate Alleviates EnterotoxigenicFrontiers in microbiology · 2022Article
- A Systematic Study of the Antioxidant Capacity of Humic Substances against Peroxyl Radicals: Relation to Structure.Polymers · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sodium humate (HA-Na) has been topically used as a wound healing and anti-inflammatory agent in folk medicine. In the present study, HA-Na was investigated for cutaneous wound healing in Sprague-Dawley rats. HA-Na solution (1.0%, w/v) was topically administered to rats undergoing excision wound models. Healing was assessed with a recombinant bovine basic fibroblast growth factor for external use as positive control. Wound healing rates were calculated on Day 3, 6, 9, 14 and 21 after injury, and tissues were also harvested after the same intervals for histological analysis. In addition, tissue hydroxyproline levels were measured. Furthermore, mRNA levels and protein expressions of transforming growth factor-β1, 2, 3 (TGF-β1, 2, 3) were determined by RT-PCR and western blot. Protein expression levels of Smad-2, -3, -4 and -7 were also detected by western blot. Our study demonstrates that HA-Na has the capacity to promote wound healing in rats via accelerated wound contraction and increased hydroxyproline content. More importantly, these wound healing effects of HA-Na might be mediated through the TGF-β/Smad signaling pathway. HA-Na may be an effective agent for enhanced wound healing.
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Registered trials
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