Evidence map›Paper›PMID 27006833›Full record

ReviewNeural plasticity2016

Models to Tailor Brain Stimulation Therapies in Stroke.

E B Plow, V Sankarasubramanian, D A Cunningham, K Potter-Baker, N Varnerin, L G Cohen, A Sterr, A B Conforto, A G Machado

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
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  3. Combining transcranial direct current stimulation with aerobic exercise to optimize cortical priming in stroke.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2021
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  7. Inhibition versus facilitation of contralesional motor cortices in stroke: Deriving a model to tailor brain stimulation.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

E B PlowDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
V SankarasubramanianDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
D A CunninghamDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA; School of Biomedical Sciences, Kent State University, Kent, OH 44242, USA.
K Potter-BakerDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
N VarnerinDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
L G CohenHuman Cortical Physiology and Stroke Neurorehabilitation Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA.
A SterrUniversity of Surrey, Guildford, Surrey GU2 7XH, UK.
A B ConfortoNeurology Clinical Division, Neurology Department, Hospital das Clinicas, Sao Paulo University, 05508-090 Sao Paulo, SP, Brazil; Hospital Israelita Albert Einstein, 05652-900 Sao Paulo, SP, Brazil.
A G MachadoCenter for Neurological Restoration, Neurosurgery, Neurological Institute, Cleveland Clinic Foundation, Cleveland Clinic, Cleveland, OH 44195, USA.
Cleveland Clinic · USHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRNational Institute of Neurological Disorders and Stroke · USUniversity of Surrey · GB

Funding

Dentatothalamocortical electrical stimulation in post-stroke motor recoveryR01HD061363 · NICHD · CLEVELAND CLINIC LERNER COM-CWRU · PI MACHADO, ANDRE GUELMAN · 2010 to 2014
$1.5M
Brain Stimulation- aided Stroke Rehabilitation: Neural Mechanisms of RecoveryK01HD069504 · NICHD · CLEVELAND CLINIC LERNER COM-CWRU · PI PLOW, ELA B · 2011 to 2015
$531k
NICHD NIH HHS 1K01HD069504NICHD NIH HHS 5R01HD061363NICHD NIH HHS K01 HD069504NICHD NIH HHS R01 HD061363NINDS NIH HHS 5R01NS07634
6 · The paper itself

Abstract

A great challenge facing stroke rehabilitation is the lack of information on how to derive targeted therapies. As such, techniques once considered promising, such as brain stimulation, have demonstrated mixed efficacy across heterogeneous samples in clinical studies. Here, we explain reasons, citing its one-type-suits-all approach as the primary cause of variable efficacy. We present evidence supporting the role of alternate substrates, which can be targeted instead in patients with greater damage and deficit. Building on this groundwork, this review will also discuss different frameworks on how to tailor brain stimulation therapies. To the best of our knowledge, our report is the first instance that enumerates and compares across theoretical models from upper limb recovery and conditions like aphasia and depression. Here, we explain how different models capture heterogeneity across patients and how they can be used to predict which patients would best respond to what treatments to develop targeted, individualized brain stimulation therapies. Our intent is to weigh pros and cons of testing each type of model so brain stimulation is successfully tailored to maximize upper limb recovery in stroke.

Indexed as

Neuronal PlasticityRecovery of FunctionAnimalsBrainHumansMotor CortexStroke RehabilitationTranscranial Direct Current StimulationTranscranial Magnetic StimulationTreatment Outcome

Identifiers

PMID27006833
PMCPMC4781989
OpenAlexW2291171723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.