ReviewJournal of obesity2016
Bile Acids, FXR, and Metabolic Effects of Bariatric Surgery.
Review in Journal of obesity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Cholecystectomy - a potential selection bias in studies assessing the metabolic effects of bariatric surgeries.Scientific reports · 2020Trial
- Unraveling the enterohepatic paradigm in sleeve gastrectomy: bile acids lead, microbiome follows.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Hypoglycemic Activity of Rice Resistant-Starch Metabolites: A Mechanistic Network Pharmacology and In Vitro Approach.Metabolites · 2024Article
- Plasma SHBG Levels as an Early Predictor of Response to Bariatric Surgery.Obesity surgery · 2024Article
- Association of Metabolomic Biomarkers with Sleeve Gastrectomy Weight Loss Outcomes.Metabolites · 2023Article
- Reversal of NAFLD After VSG Is Independent of Weight-Loss but RYGB Offers More Efficacy When Maintained on a High-Fat Diet.Obesity surgery · 2022Article
- The effect of bile salt diet supplementation on genes related to fat metabolism in yellow-feathered broilers.Veterinary world · 2022Article
- Bile acids-gut microbiota crosstalk contributes to the improvement of type 2 diabetes mellitus.Frontiers in pharmacology · 2022Review
- Diagnostic Value of Bile Acids and Fibroblast Growth Factor 21 in Women with Polycystic Ovary Syndrome.Women's health reports (New Rochelle, N.Y.) · 2022Article
- Reversal and Remission of T2DM - An Update for Practitioners.Vascular health and risk management · 2022Review
- Serum Levels and Adipose Tissue Gene Expression of Cathelicidin Antimicrobial Peptide (CAMP) in Obesity and During Weight Loss.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2021Article
- Barocrinology: The Endocrinology of Obesity from Bench to Bedside.Medical sciences (Basel, Switzerland) · 2020Review
- Farnesoid X receptor - a molecular predictor of weight loss after vertical sleeve gastrectomy?Obesity science & practice · 2019Article
- Problematic Eating Behaviors and Eating Disorders Associated with Bariatric Surgery.The Psychiatric clinics of North America · 2019Review
- Systemic bile acids induce insulin resistance in a TGR5-independent manner.American journal of physiology. Endocrinology and metabolism · 2019Article
- Metabolic and Endocrine Consequences of Bariatric Surgery.Frontiers in endocrinology · 2019Review
- Sitagliptin and Roux-en-Y gastric bypass modulate insulin secretion via regulation of intra-islet PYY.Diabetes, obesity & metabolism · 2018Article
- Proceedings of the 2017 ASPEN Research Workshop-Gastric Bypass: Role of the Gut.JPEN. Journal of parenteral and enteral nutrition · 2018Review
- Bile acid signaling and bariatric surgery.Liver research (Beijing, China) · 2017Article
- The role of bile acids in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.Molecular aspects of medicine · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Overweight and obesity represent major risk factors for diabetes and related metabolic diseases. Obesity is associated with a chronic and progressive inflammatory response leading to the development of insulin resistance and type 2 diabetes (T2D) mellitus, although the precise mechanism mediating this inflammatory process remains poorly understood. The most effective intervention for the treatment of obesity, bariatric surgery, leads to glucose normalization and remission of T2D. Recent work in both clinical studies and animal models supports bile acids (BAs) as key mediators of these effects. BAs are involved in lipid and glucose homeostasis primarily via the farnesoid X receptor (FXR) transcription factor. BAs are also involved in regulating genes involved in inflammation, obesity, and lipid metabolism. Here, we review the novel role of BAs in bariatric surgery and the intersection between BAs and immune, obesity, weight loss, and lipid metabolism genes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.