Evidence map›Paper›PMID 27006715›Full record

ArticleThe open cardiovascular medicine journal2015

Angiotensinogen (AGT) M235T, AGT T174M and Angiotensin-1-Converting Enzyme (ACE) I/D Gene Polymorphisms in Essential Hypertension: Effects on Ramipril Efficacy.

Vana Kolovou, Evangelia Lagou, Constantinos Mihas, Giannakopoulou Vasiliki, Niki Katsiki, Aikaterini Kollia, Filippos Triposkiadis, Dimitris Degiannis, Sophie Mavrogeni, Genovefa Kolovou

Open access · diamondAbstract read
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In one paragraph

Article in The open cardiovascular medicine journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. The Association of M235T Genetic Polymorphism inJournal of personalized medicine · 2024
    Article
  5. Review
  6. Correlation ofPharmacogenomics · 2024
    Observational
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  8. Article
  9. Article
  10. Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Vana KolovouCardiology Department, Molecular Immunology Laboratory, Onassis Cardiac Surgery Center Athens, Greece; Molecular Immunology Laboratory, Onassis Cardiac Surgery Center Athens, Greece.
Evangelia LagouMolecular Immunology Laboratory, Onassis Cardiac Surgery Center Athens, Greece.
Constantinos MihasInternal Medicine Department, General Hospital of Kimi, Evia Island, Greece.
Giannakopoulou VasilikiCardiology Department, Thriassio Hospital, Magoula, Greece.
Niki KatsikiSecond Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece.
Aikaterini KolliaOrthopedic and Urologic Departments, Veterans Administration Hospital (NIMTS), Athens, Greece.
Filippos TriposkiadisDepartment of Cardiology, Larissa University Hospital, Larissa, Greece.
Dimitris DegiannisMolecular Immunology Laboratory, Onassis Cardiac Surgery Center Athens, Greece.
Sophie MavrogeniCardiology Department, Molecular Immunology Laboratory, Onassis Cardiac Surgery Center Athens, Greece.
Genovefa KolovouCardiology Department, Molecular Immunology Laboratory, Onassis Cardiac Surgery Center Athens, Greece.
Onassis Cardiac Surgery Center · GRInstitute of Cardiology · PLAristotle University of Thessaloniki · GRNIMTS Hospital · GRThriasio General Hospital of Elefsina · GRUniversity Hospital of Larissa · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypertension, one of the most important risk factors for premature cardiovascular disease, is a major worldwide public health problem. Angiotensin-1-converting enzyme (ACE) and angiotensinogen (AGT) gene polymorphisms are thought to be associated with primary hypertension. In the present study, we examined the frequency of these gene polymorphisms in an adult population with and without essential hypertension. Furthermore, we evaluated the effect of ACE and AGT gene polymorphisms on ramipril treatment efficacy in the hypertensive patients.

methodsA total of 166 adults (83 hypertensives and 83 normotensives) were involved in the study and genotyped for AGTM235T (rs699), AGTT174M (rs4762) and ACEI/D (rs1799752) gene polymorphisms.

resultsThe genotype and allele distribution of the AGTM235T variant significantly differed between hypertensives and normotensives [odds ratio (OR) = 1.57% (T vs M allele), 95% confidence intervals (CIs): 1.01 - 2.44; p=0.045 for hypertensives]. However, none of the 3 studied Simple Nucleotide Polymorphisms were associated with the blood pressure-lowering response to ramipril.

conclusionThese results suggest that AGTM235T gene polymorphism is associated with essential hypertension. However, none of the AGTM235T, AGTT174M and ACEI/D gene polymorphisms influenced ramipril effectiveness.

Indexed as

ACEI/D gene polymorphismsAGTM235TAGTT174efficacyhypertensionramipril.

Identifiers

PMID27006715
PMCPMC4768660
OpenAlexW2204074094

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.