Evidence map›Paper›PMID 27006714›Full record

ArticleThe open cardiovascular medicine journal2015

Successful Direct Adsorption of Lipoproteins (DALI) Apheresis During Pregnancy in an Omani Woman with Homozygous Familial Hypercholesterolemia.

Tamima Al-Dughaishi, Khalid Al-Waili, Yajnavalka Banerjee, Shahila Sheik, Hilal Al-Sabti, Ibrahim Al-Zakwani, Suad Al-Mukhaini, Khalifa Al Wahaibi, Ali T Al-Hinai, Khalid Al-Rasadi

Open access · diamondAbstract read
In one paragraph

Article in The open cardiovascular medicine journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Tamima Al-DughaishiDepartment of Obstetrics & Gynecology, Sultan Qaboos University Hospital, Muscat, Oman.
Khalid Al-WailiDepartment of Clinical Biochemistry, Sultan Qaboos University Hospital, Muscat, Oman.
Yajnavalka BanerjeeDepartment of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman.
Shahila SheikDepartment of Obstetrics & Gynecology, Sultan Qaboos University Hospital, Muscat, Oman.
Hilal Al-SabtiDepartment of Surgery, Cardiothoracic Unit, Sultan Qaboos University Hospital, Muscat, Oman.
Ibrahim Al-ZakwaniDepartment of Pharmacology and Clinical Pharmacy, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman; Gulf Health Research, Muscat, Oman.
Suad Al-MukhainiDepartment of Nursing, Sultan Qaboos University Hospital, Muscat, Oman.
Khalifa Al WahaibiDepartment of Surgery, Vascular Unit, Sultan Qaboos University Hospital, Muscat, Oman.
Ali T Al-HinaiMinistry of Health, Muscat, Oman.
Khalid Al-RasadiDepartment of Clinical Biochemistry, Sultan Qaboos University Hospital, Muscat, Oman.
Sultan Qaboos University Hospital · OMSultan Qaboos University · OMMinistry of Health · OM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report our experience with Direct Adsorption of Lipoproteins (DALI) apheresis in an Omani pregnant woman affected by homozygous familial hypercholesterolemia. To the best of our knowledge this is the first successful pregnancy treated with DALI apheresis. The patient had a history of coronary artery disease, supra-aortic valvular stenosis and severe carotid artery disease with right carotid artery stenting. She was on a regular biweekly DALI apheresis since 2008. In May 2013, she became pregnant and rosuvastatin and ezetimibe were stopped while she continued on DALI apheresis biweekly. This treatment during pregnancy was successful with no major complications. The average low-density lipoprotein cholesterol reduction during therapy was 50%. She spontaneously delivered a healthy male infant (2,400 g) at 37 weeks. We showed that DALI apheresis therapy was safe during pregnancy with a good outcome for both mother and neonate.

Indexed as

Familial hypercholesterolemiaLDL-apheresislow density lipoprotein receptorpregnancyxanthoma

Identifiers

PMID27006714
PMCPMC4768655
OpenAlexW2217122015

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.