ArticleInternational journal of microbiology2016
Synergistic Interaction of Methanol Extract from Canarium odontophyllum Miq. Leaf in Combination with Oxacillin against Methicillin-Resistant Staphylococcus aureus (MRSA) ATCC 33591.
Article in International journal of microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
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- Phytochemical composition and bioactivities of Saudi endemic Reseda pentagyna essential oils.Scientific reports · 2026Article
- Phytochemical composition, in vitro antioxidant and antibacterial activities of Dorstenia barnimiana Schweinf leaf extracts.BMC complementary medicine and therapies · 2026Article
- Chemical Composition, Antimicrobial, Antioxidant, and Anticancer Activities ofMolecules (Basel, Switzerland) · 2026Article
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- Bioactive Compounds, Antibacterial, Antioxidant, Anticancer, and Antidiabetic Potential of the Seed and Leaves ofLife (Basel, Switzerland) · 2025Article
- Synergistic antibacterial activity and prevention of drug resistance of daptomycin combined with fosfomycin against methicillin-resistantAntimicrobial agents and chemotherapy · 2025Article
- In Vitro Evaluation, Chemical Profiling, and In Silico ADMET Prediction of the Pharmacological Activities ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Superior Performance of Iron-Coated Silver Nanoparticles and Cefoxitin as an Antibiotic Composite Against Methicillin-Resistant Staphylococcus aureus (MRSA): A Population Study.Molecular biotechnology · 2024Article
- Silver nanoparticles synthesized using aerial part of Achillea fragrantissima and evaluation of their bioactivities.Scientific reports · 2024Article
- Article
- Chemical Composition, Antioxidant, Anticancer, and Antibacterial Activities of Roots and Seeds ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Acute Toxicity of Aqueous Extract fromTheScientificWorldJournal · 2024Article
- Activity of aurisin A isolated fromSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Evaluation of the antibacterial activity of selected Kenyan medicinal plant extract combinations against clinically important bacteria.BMC complementary medicine and therapies · 2023Article
- Oxidative Stress-Mediated Antibacterial Activity of the Total Flavonoid Extracted from theVeterinary sciences · 2022Article
- Evaluation of Antibacterial Synergism of Methanolic Extract of Dracocephalum kotschyi and Trachyspermum ammi.The Malaysian journal of medical sciences : MJMS · 2021Article
- The Inhibition Effect of Linezolid With Reyanning Mixture on MRSA and its Biofilm is More Significant than That of Linezolid Alone.Frontiers in pharmacology · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Canarium odontophyllum (CO) Miq. has been considered as one of the most sought-after plant species in Sarawak, Malaysia, due to its nutritional and pharmacological benefits. This study aimed to evaluate the pharmacodynamic interaction of crude methanol and acetone extracts from CO leaves in combination with oxacillin, vancomycin, and linezolid, respectively, against MRSA ATCC 33591 as preliminary study has reported its potential antistaphylococcal activity. The broth microdilution assay revealed that both methanol and acetone extracts were bactericidal with Minimum Inhibitory Concentration (MIC) of 312.5 μg/mL and 156.25 μg/mL and Minimum Bactericidal Concentration (MBC) of 625 μg/mL and 312.5 μg/mL, respectively. Fractional Inhibitory Concentration (FIC) indices were obtained via the chequerboard dilution assay where methanol extract-oxacillin, acetone extract-oxacillin, methanol extract-linezolid, and acetone extract-linezolid combinations exhibited synergism (FIC index ≤ 0.5). The synergistic action of the methanol extract-oxacillin combination was verified by time-kill analysis where bactericidal effect was observed at concentration of 1/8 × MIC of both compounds at 9.6 h compared to oxacillin alone. As such, these findings postulated that both extracts exert their anti-MRSA mechanism of action similar to that of vancomycin and provide evidence that the leaves of C. odontophyllum have the potential to be developed into antistaphylococcal agents.
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