ArticleThe Journal of allergy and clinical immunology2016
Relationship between lung function and quantitative computed tomographic parameters of airway remodeling, air trapping, and emphysema in patients with asthma and chronic obstructive pulmonary disease: A single-center study.
Article in The Journal of allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 112 citations in OpenAlex.
- Imaging Markers of Chronic Obstructive Pulmonary Disease on Computed Tomography of the Lungs: a Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Biologic Therapy Is Associated with Reduced Pleural-Line Thickness in Severe Asthma: A Prospective Transthoracic Ultrasound Study.Journal of clinical medicine · 2026Article
- Automated identification of chronic obstructive pulmonary disease and asthma using impulse oscillometry combined with quantitative computed tomography parameters and radiomics features.Journal of thoracic disease · 2026Article
- LAPTM5 potentiates airway remodeling by regulating MAPKs-mediated airway smooth muscle cells' dysfunction.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Computed Tomography-Based Evaluation of Airway Remodeling for Distinguishing Asthma-Chronic Obstructive Pulmonary Disease Overlap From Asthma and Chronic Obstructive Pulmonary Disease.Canadian respiratory journal · 2026Article
- Established and Emerging Asthma Biomarkers with a Focus on Biologic Trials: A Narrative Review.Journal of personalized medicine · 2025Review
- Quantitative Computed Tomography Biomarkers of Emphysema Severity in Chronic Obstructive Pulmonary Disease: Insights from Muscle Mass, Fat Volume, and Vascular Dimensions.Advanced biomedical research · 2025Article
- Associated Factors and Pulmonary Function Outcomes of Preserved Ratio Impaired Spirometry: A Scoping Review.International journal of chronic obstructive pulmonary disease · 2025Article
- Increased expression of cathepsin C in airway epithelia exacerbates airway remodeling in asthma.JCI insight · 2024Article
- The epithelial era of asthma research: knowledge gaps and future direction for patient care.European respiratory review : an official journal of the European Respiratory Society · 2024Review
- The New Paradigm: The Role of Proteins and Triggers in the Evolution of Allergic Asthma.International journal of molecular sciences · 2024Review
- Long-term efficacy of house dust mite sublingual immunotherapy on clinical and pulmonary function in patients with asthma and allergic rhinitis.The journal of allergy and clinical immunology. Global · 2024Article
- Airway remodelling in asthma and the epithelium: on the edge of a new era.The European respiratory journal · 2024Review
- Evaluation of retrieval accuracy and visual similarity in content-based image retrieval of chest CT for obstructive lung disease.Scientific reports · 2024Article
- Differences in the Quantitative HRCT Characteristics of Patients with Asthma, COPD and Asthma-COPD Overlap and Their Relationships with Pulmonary Function.International journal of chronic obstructive pulmonary disease · 2024Article
- Functional imaging in asthma and COPD: design of the NOVELTY ADPro substudy.ERJ open research · 2023Article
- Relationships Between High-Resolution Computed Tomographic Features and Lung Function Trajectory in Patients With Asthma.Allergy, asthma & immunology research · 2023Article
- How does cigarette smoking affect airway remodeling in asthmatics?Tobacco induced diseases · 2023Review
- Early Diagnosis of High-Risk Chronic Obstructive Pulmonary Disease Based on Quantitative High-Resolution Computed Tomography Measurements.International journal of chronic obstructive pulmonary disease · 2023Article
- Biologics and airway remodeling in severe asthma.Allergy · 2022Review
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundThere is a paucity of studies comparing asthma and chronic obstructive pulmonary disease (COPD) based on thoracic quantitative computed tomographic (QCT) parameters.
objectivesWe sought to compare QCT parameters of airway remodeling, air trapping, and emphysema between asthmatic patients and patients with COPD and explore their relationship with airflow limitation.
methodsAsthmatic patients (n = 171), patients with COPD (n = 81), and healthy subjects (n = 49) recruited from a single center underwent QCT and clinical characterization.
resultsProximal airway percentage wall area (%WA) was significantly increased in asthmatic patients (62.5% [SD, 2.2]) and patients with COPD (62.7% [SD, 2.3]) compared with that in healthy control subjects (60.3% [SD, 2.2], P < .001). Air trapping measured based on mean lung density expiratory/inspiratory ratio was significantly increased in patients with COPD (mean, 0.922 [SD, 0.037]) and asthmatic patients (mean, 0.852 [SD, 0.061]) compared with that in healthy subjects (mean, 0.816 [SD, 0.066], P < .001). Emphysema assessed based on lung density measured by using Hounsfield units below which 15% of the voxels lie (Perc15) was a feature of COPD only (patients with COPD: mean, -964 [SD, 19.62] vs asthmatic patients: mean, -937 [SD, 22.7] and healthy subjects: mean, -937 [SD, 17.1], P < .001). Multiple regression analyses showed that the strongest predictor of lung function impairment in asthmatic patients was %WA, whereas in the COPD and asthma subgrouped with postbronchodilator FEV1 percent predicted value of less than 80%, it was air trapping. Factor analysis of QCT parameters in asthmatic patients and patients with COPD combined determined 3 components, with %WA, air trapping, and Perc15 values being the highest loading factors. Cluster analysis identified 3 clusters with mild, moderate, or severe lung function impairment with corresponding decreased lung density (Perc15 values) and increased air trapping.
conclusionsIn asthmatic patients and patients with COPD, lung function impairment is strongly associated with air trapping, with a contribution from proximal airway narrowing in asthmatic patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.