Observational studyInternational orthopaedics2017
The impact of mild peri-operative hypothermia on the effectiveness of tranexamic acid in total hip arthroplasty.
Observational study in International orthopaedics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Pooled it
- Topical versus intravenous tranexamic acid in total knee arthroplasty: a meta-analysis of randomized controlled trials.International orthopaedics · 2017Pooled it
- Effectiveness of different doses and routes of administration of tranexamic acid for total hip replacement.International orthopaedics · 2021Trial
- [Efficacy and safety of a loading high-dose tranexamic acid followed by postoperative five doses in total hip arthroplasty: A randomized controlled trial].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2019Trial
- Low-dose erythropoietin in anemic arthroplasty patients within contemporary patient blood management pathways.Journal of orthopaedic surgery and research · 2026Article
- Does perioperative hypothermia after primary total hip and knee arthroplasty affect acute outcomes?Journal of orthopaedics · 2025Article
- Blood management protocol for baseline anemic patients undergoing hip arthroplasty.Archives of orthopaedic and trauma surgery · 2025Article
- An observational study of an adjusted patient blood management protocol intended to lower rates of transfusion following total knee arthroplasty in patients with preoperative anemia.Journal of orthopaedic surgery and research · 2023Article
- Analysis of the effects of intraoperative warming devices on surgical site infection in elective hip arthroplasty using a large nationwide database.Archives of orthopaedic and trauma surgery · 2023Article
- Dexamethasone with aggressive warming facilitates pain reduction, reduced blood loss, and quicker recovery after total hip arthroplasty.Scientific reports · 2023Article
- Application of an adjusted patient blood management protocol in patients undergoing elective total hip arthroplasty: towards a zero-percent transfusion rate in renal patients-results from an observational cohort study.Journal of orthopaedic surgery and research · 2021Observational
- Surgical prescription of epoetin alfa in contemporary total hip arthroplasty: a prospective comparative study.International orthopaedics · 2020Article
- The forgotten joint score in total and unicompartmental knee arthroplasty: a prospective cohort study.International orthopaedics · 2019Article
- Use of a fibrin sealant within a blood-saving protocol in patients undergoing revision hip arthroplasty: effects on post-operative blood transfusion and healthcare-related cost analysis.International orthopaedics · 2019Observational
- Improved patient blood management and cost saving in hip replacement surgery through the implementation of pre-operative Sucrosomial® iron supplementation: a quality improvement assessment study.International orthopaedics · 2019Article
- Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSurgical patients experience inadvertent hypothermia as a result of anaesthesia-induced thermoregulatory impairment. Previous studies have found that hypothermia is associated with increased blood loss and transfusion requirements. This study examined the incidence of hypothermia in patients undergoing total hip arthroplasty (THA), whether hypothermia is associated with increased blood loss, and whether any such association is modified by tranexamic acid (TXA) administration.
methodsAn observational prospective study was performed in 941 consecutive patients undergoing elective THA, with and without intra-operative administration of TXA. The presence of hypothermia on post-anaesthesia care unit admission was determined, and the post-operative bleeding index calculated. Transfusions and complications were documented.
resultsThe incidence of peri-operative inadvertent hypothermia was 84.2 %. TXA was administered to 751 (79.8 %) patients. The bleeding index was 2.6 (95 % confidence interval [CI] 2.6-2.7) in patients treated with TXA and 3.1 (95 % CI 2.8-3.4) in patients who did not receive TXA (p = 0.012). Mild hypothermia did not have a significant impact on the bleeding index (difference, -0.4; 95 % CI, -1.1 to +0.2; p = 0.190), nor on the effectiveness of TXA (difference, 0.4; 95 % CI, -0.3 to +1.1; p = 0.250).
conclusionThe incidence of hypothermia in our THA population was high, despite peri-operative air warming. However, mild hypothermia was not significantly associated with increased blood loss and did not reduce the effectiveness of TXA.
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