ArticleScientific reports2016
Human sperm rheotaxis: a passive physical process.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- A sperm racetrack to separate sperm by swim speed.Lab on a chip · 2026Article
- Swimming patterns of a multi-mode bacterial swimmer in fluid shear flow.Biophysical journal · 2026Article
- Separation of sperm based on rheotaxis mechanism using a microfluidic device.Clinical and experimental reproductive medicine · 2026Article
- Physics of microbial taxis and behaviours in response to various physical stimuli.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Review
- Simple and rapid microfluidic device for processing raw human semen and separation of motile sperm based on their intrinsic behavior and morphology.Scientific reports · 2025Article
- Sperm navigation in humans: a concerted action of multiple means.Communications biology · 2025Review
- Tunable motile sperm separation based on sperm persistence in migrating through shear barriers.Biomicrofluidics · 2024Article
- Review
- Microfluidics-A novel technique for high-quality sperm selection for greater ART outcomes.FASEB bioAdvances · 2024Review
- Impact of various cryo-preservation steps on sperm rheotaxis and sperm kinematics in bull.Scientific reports · 2024Article
- Spermbots and Their Applications in Assisted Reproduction: Current Progress and Future Perspectives.International journal of nanomedicine · 2024Review
- Human sperm cooperate to transit highly viscous regions on the competitive pathway to fertilization.Communications biology · 2023Article
- Sperm selection by the oviduct: perspectives for male fertility and assisted reproductive technologies†.Biology of reproduction · 2023Article
- A novel microfluidic device with parallel channels for sperm separation using spermatozoa intrinsic behaviors.Scientific reports · 2023Article
- Lab-on-chip (LoC) application for quality sperm selection: An undelivered promise?Open research Europe · 2023Review
- β-Defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility.Cell reports. Medicine · 2022Article
- A novel Human Conception Optimizer for solving optimization problems.Scientific reports · 2022Article
- Separation of motile human sperms in a T-shaped sealed microchannel.Biomedical engineering letters · 2022Article
- Review
- Simulating nature in sperm selection for assisted reproduction.Nature reviews. Urology · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A long-standing question in natural reproduction is how mammalian sperm navigate inside female reproductive tract and finally reach the egg cell, or oocyte. Recently, fluid flow was proposed as a long-range guidance cue for sperm navigation. Coitus induces fluid flow from oviduct to uterus, and sperm align themselves against the flow direction and swim upstream, a phenomenon termed rheotaxis. Whether sperm rheotaxis is a passive process dominated by fluid mechanics, or sperm actively sense and adapt to fluid flow remains controversial. Here we report the first quantitative study of sperm flagellar motion during human sperm rheotaxis and provide direct evidence indicating that sperm rheotaxis is a passive process. Experimental results show that there is no significant difference in flagellar beating amplitude and asymmetry between rheotaxis-turning sperm and those sperm swimming freely in the absence of fluid flow. Additionally, fluorescence image tracking shows no Ca(2+) influx during sperm rheotaxis turning, further suggesting there is no active signal transduction during human sperm rheotaxis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.