Evidence map›Paper›PMID 27005674›Full record

ArticleWorld journal of surgical oncology2016

Two cases of gallbladder metastasis from renal cell carcinoma and review of literature.

Mafalda Costa Neves, Kyriakos Neofytou, Alexandros Giakoustidis, Stephen Hazell, Andrew Wotherspoon, Martin Gore, Satvinder Mudan

Abstract readCase Reports
In one paragraph

Article in World journal of surgical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Rare occurrence of small bowel intussusception due to synchronous metastasis of renal cell carcinoma.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Imaging of gallbladder metastasis.Insights into imaging · 2021
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Uncommon site of metastasis from renal cell carcinoma: Case report.International journal of surgery case reports · 2019
    Article
  11. Renal Cell Carcinoma Metastatic to the Gallbladder.Journal of gastrointestinal cancer · 2018
    Article
  12. Gallbladder Metastasis from Renal Cell Carcinoma.The Indian journal of surgery · 2018
    Article
  13. Cystic Duct Metastasis from Renal Cell Carcinoma.Internal medicine (Tokyo, Japan) · 2018
    Article
  14. Unexpected Gallbladder Metastasis of Clear Cell Renal Carcinoma.Clinical pathology (Thousand Oaks, Ventura County, Calif.)
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mafalda Costa NevesAcademic Surgery Department, The Royal Marsden NHS Foundation Trust, Fulham Road, London, SW3 6JJ, UK. mafaldajardim@hotmail.com.
Kyriakos NeofytouAcademic Surgery Department, The Royal Marsden NHS Foundation Trust, Fulham Road, London, SW3 6JJ, UK.
Alexandros GiakoustidisSurgery Department, The London Clinic, 116 Harley Street, London, W1G 7JL, UK.
Stephen HazellPathology Department, The Royal Marsden NHS Foundation Trust, Fulham Road, London, SW3 6JJ, UK.
Andrew WotherspoonPathology Department, The Royal Marsden NHS Foundation Trust, Fulham Road, London, SW3 6JJ, UK.
Martin GoreUrology Department, The Royal Marsden NHS Foundation Trust, Fulham Road, London, SW3 6JJ, UK.
Satvinder MudanAcademic Surgery Department, The Royal Marsden NHS Foundation Trust, Fulham Road, London, SW3 6JJ, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRenal cell carcinoma accounts for 90% of renal neoplasms and metastatic disease is common. One third of newly diagnosed cases will have synchronous metastases at diagnosis and further 25-50 % will develop metachronous disease. CASE PRESENTATION: This study presents two new cases of gallbladder metastasis from renal cell carcinoma (RCC) from our institution and reviews the published literature. The final cohort included 52 evaluable patients. M/F ratio was 2:1 and median age was 62.5 years. Most patients were diagnosed incidentally after follow-up or staging imaging for RCC. Of the patients with available histology, all except one were clear cell type (n = 39) and 92% were polypoid. Thirty-six patients demonstrated metachronous gallbladder metastasis with median disease-free interval (DFI) from nephrectomy of 4 years. The most frequent site of metastasis was the contralateral kidney (46.7%) followed by the pancreas and lung. The median disease-free interval (DFS) after cholecystectomy was 37 months. Three- and five-year OS rates were 74 and 62%, respectively. Age younger than 45 years (p = 0.008) and DFI <24 months (p = 0.049) were associated with decreased OS.

conclusionsRCC metastasis to the gallbladder is associated with an unusual pattern of concomitant metastasis. Symptoms are not common. Simple cholecystectomy is associated with increased OS and nil local or port site recurrence. Young age and short DFI are associated with decreased OS.

Indexed as

Carcinoma, Renal CellCholecystectomyFemaleGallbladder NeoplasmsHumansKidney NeoplasmsMaleMiddle AgedPrognosisCancerClear cell metastatic renal cell carcinomaGallbladderKidney neoplasms

Identifiers

PMID27005674
PMCPMC4802731

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.