ArticleEvolution; international journal of organic evolution2016
Parasite diversity drives rapid host dynamics and evolution of resistance in a bacteria-phage system.
Article in Evolution; international journal of organic evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Sequential Phage Delivery Can Outperform Cocktails by Delaying Cross-Resistance Evolution.Viruses · 2026Article
- Integrating the Microbiome Into Infection Ecology and Evolution in Wild Animals.Molecular ecology · 2026Review
- Review
- Ecological partitioning enables phage-antibiotic cooperation in a human Pseudomonas infection.Nature communications · 2026Article
- Rapid adaptation accelerates competitive suppression in a parasite community.The ISME journal · 2026Article
- Genome-guided isolation and characterization of a novel bacteriophage infectingFrontiers in microbiology · 2026Article
- Optical Density-Based Methods in Phage Biology: Titering, Lysis Timing, Host Range, and Phage-Resistance Evolution.Viruses · 2025Review
- Factors Affecting Phage-Bacteria Coevolution Dynamics.Viruses · 2025Review
- Warming alters life-history traits and competition in a phage community.Applied and environmental microbiology · 2024Article
- Phage combination alleviates bacterial leaf blight of rice (Frontiers in plant science · 2023Article
- Should Bacteriophages Be Classified as Parasites or Predators?Polish journal of microbiology · 2022Review
- The genetic basis of phage susceptibility, cross-resistance and host-range inMicrobiology (Reading, England) · 2021Article
- Antiviral Resistance and Phage Counter Adaptation to Antibiotic-Resistant Extraintestinal PathogenicmBio · 2021Article
- Phylogenetically diverse diets favor more complex venoms in North American pitvipers.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Mucoidy, a general mechanism for maintaining lytic phage in populations of bacteria.FEMS microbiology ecology · 2020Article
- Steering Phages to Combat Bacterial Pathogens.Trends in microbiology · 2020Review
- Phage combination therapies for bacterial wilt disease in tomato.Nature biotechnology · 2019Article
- Resistance Evolution against Phage Combinations Depends on the Timing and Order of Exposure.mBio · 2019Article
- Cross-resistance is modular in bacteria-phage interactions.PLoS biology · 2018Article
- High parasite diversity accelerates host adaptation and diversification.Science (New York, N.Y.) · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Host-parasite evolutionary interactions are typically considered in a pairwise species framework. However, natural infections frequently involve multiple parasites. Altering parasite diversity alters ecological and evolutionary dynamics as parasites compete and hosts resist multiple infection. We investigated the effects of parasite diversity on host-parasite population dynamics and evolution using the pathogen Pseudomonas aeruginosa and five lytic bacteriophage parasites. To manipulate parasite diversity, bacterial populations were exposed for 24 hours to either phage monocultures or diverse communities containing up to five phages. Phage communities suppressed host populations more rapidly but also showed reduced phage density, likely due to interphage competition. The evolution of resistance allowed rapid bacterial recovery that was greater in magnitude with increases in phage diversity. We observed no difference in the extent of resistance with increased parasite diversity, but there was a profound impact on the specificity of resistance; specialized resistance evolved to monocultures through mutations in a diverse set of genes. In summary, we demonstrate that parasite diversity has rapid effects on host-parasite population dynamics and evolution by selecting for different resistance mutations and affecting the magnitude of bacterial suppression and recovery. Finally, we discuss the implications of phage diversity for their use as biological control agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.