ArticleScientific reports2016
Population-genetic properties of differentiated copy number variations in cattle.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Population-level gene copy number variations reveal distinct genetic properties of different Malus species.BMC genomics · 2025Article
- Mapping and functional characterization of structural variation in 1060 pig genomes.Genome biology · 2024Article
- Copy number variant scan in more than four thousand Holstein cows bred in Lombardy, Italy.PloS one · 2024Article
- Gene-by-environment interactions influence the fitness cost of gene copy-number variation in yeast.G3 (Bethesda, Md.) · 2023Article
- Copy Number Variation Discovery in South African Nguni-Sired and Bonsmara-Sired Crossbred Cattle.Animals : an open access journal from MDPI · 2023Article
- Gene-by-environment interactions influence the fitness cost of gene copy-number variation in yeast.bioRxiv : the preprint server for biology · 2023Article
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- Identification of Copy Number Variations and Genetic Diversity in Italian Insular Sheep Breeds.Animals : an open access journal from MDPI · 2022Article
- Recent advances and current challenges in population genomics of structural variation in animals and plants.Frontiers in genetics · 2022Review
- Copy number variation underlies complex phenotypes in domestic dog breeds and other canids.Genome research · 2021Article
- Insights into adaption and growth evolution: a comparative genomics study on two distinct cattle breeds from Northern and Southern China.Molecular therapy. Nucleic acids · 2021Article
- Identification and population genetic analyses of copy number variations in six domestic goat breeds and Bezoar ibexes using next-generation sequencing.BMC genomics · 2020Article
- Comparative analyses of copy number variations between Bos taurus and Bos indicus.BMC genomics · 2020Article
- Genomic Structural Diversity in Local Goats: Analysis of Copy-Number Variations.Animals : an open access journal from MDPI · 2020Article
- AthCNV: A Map of DNA Copy Number Variations in the Arabidopsis Genome.The Plant cell · 2020Article
- Whole genome resequencing of the Iranian native dogs and wolves to unravel variome during dog domestication.BMC genomics · 2020Article
- Functional and population genetic features of copy number variations in two dairy cattle populations.BMC genomics · 2020Article
- Inter- and intra-breed genome-wide copy number diversity in a large cohort of European equine breeds.BMC genomics · 2019Article
- Polar bear evolution is marked by rapid changes in gene copy number in response to dietary shift.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
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9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While single nucleotide polymorphism (SNP) is typically the variant of choice for population genetics, copy number variation (CNV) which comprises insertion, deletion and duplication of genomic sequence, is an informative type of genetic variation. CNVs have been shown to be both common in mammals and important for understanding the relationship between genotype and phenotype. However, CNV differentiation, selection and its population genetic properties are not well understood across diverse populations. We performed a population genetics survey based on CNVs derived from the BovineHD SNP array data of eight distinct cattle breeds. We generated high resolution results that show geographical patterns of variations and genome-wide admixture proportions within and among breeds. Similar to the previous SNP-based studies, our CNV-based results displayed a strong correlation of population structure and geographical location. By conducting three pairwise comparisons among European taurine, African taurine, and indicine groups, we further identified 78 unique CNV regions that were highly differentiated, some of which might be due to selection. These CNV regions overlapped with genes involved in traits related to parasite resistance, immunity response, body size, fertility, and milk production. Our results characterize CNV diversity among cattle populations and provide a list of lineage-differentiated CNVs.
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