Evidence map›Paper›PMID 27005450›Full record

ReviewMicrobes and infection2016

Autonomous immunity in mucosal epithelial cells: fortifying the barrier against infection.

Karen F Ross, Mark C Herzberg

Abstract readReview
In one paragraph

Review in Microbes and infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
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  10. Review
  11. Review
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  13. Article
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  15. Article
  16. Immunomodulatory Effects of 17Journal of immunology research · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Karen F RossDepartment of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, USA.
Mark C HerzbergDepartment of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, USA. Electronic address: mcherzb@umn.edu.

Funding

S. SANGUIS ADHESION--MOLECULAR BASIS OF SPECIFICITYR01DE008590 · NIDCR · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HERZBERG, MARK C · 1990 to 2009
$3.7M
INNATE INTRAEPITHELIAL DEFENSE AGAINST ORAL INFECTIONR01DE011831 · NIDCR · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HERZBERG, MARK C · 1997 to 2006
$2.0M
Oral Epithelial Cells: Innate Immune "Gatekeeper" of HIVR01DE015503 · NIDCR · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HERZBERG, MARK C · 2003 to 2006
$1.3M
Augmenting Innate Immunity to Protect the Oral MucosaR01DE021206 · NIDCR · UNIVERSITY OF MINNESOTA · PI HERZBERG, MARK C · 2010 to 2013
$1.2M
Connexin-Mediated Hemichannel Activity in Experimental PeriodontitisR21DE021800 · NIDCR · UNIVERSITY OF MINNESOTA · PI JOHNSTONE, KAREN F · 2011 to 2012
$415k
HIV Modulates Oral Mucosal Calprotectin and CandidiasisR21DE015056 · NIDCR · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ROSS, KAREN F · 2003 to 2004
$371k
Training in Systems Biology for the Study of Host-Pathogen InteractionsF33DE020006 · NIDCR · UNIVERSITY OF BRITISH COLUMBIA · PI HERZBERG, MARK C · 2009 to 2009
$10k
NIDCR NIH HHS F33 DE020006NIDCR NIH HHS R01 DE008590NIDCR NIH HHS R01 DE011831NIDCR NIH HHS R01 DE015503NIDCR NIH HHS R01 DE021206NIDCR NIH HHS R21 DE015056NIDCR NIH HHS R21 DE021800
6 · The paper itself

Abstract

Mucosal epithelial cells express an autonomous innate immune response that controls the overgrowth of invaded bacteria, mitigates the harmful effects of the bacteria carried within, and does not rely on other external arms of the immune response. Epithelial cell autonomous innate immunity "respects" the social biology of invading bacteria to achieve symbiosis, and is the primary protective mechanism against pathogens.

Indexed as

Immunity, MucosalAnimalsEpithelial CellsEpitheliumHumansImmunity, InnateAntimicrobial proteinsCell signalingInfectionInnate immunityMucosal epithelium

Identifiers

PMID27005450
PMCPMC4884473

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.