Evidence map›Paper›PMID 27005424›Full record

SynthesisHuman molecular genetics2016

Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease.

Giulia Orlando, Philip J Law, Kimmo Palin, Sari Tuupanen, Alexandra Gylfe, Ulrika A Hänninen, Tatiana Cajuso, Tomas Tanskanen, Johanna Kondelin, Eevi Kaasinen and 47 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human molecular genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 7 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 7 syntheses or guidelines pooled it, 45 citations in OpenAlex.

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  16. Using DEPendency of Association on the Number of Top Hits (DEPTH) as a Complementary Tool to Identify Novel Colorectal Cancer Susceptibility Loci.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

57 authors at 20 institutions in 8 countries.

Giulia OrlandoDivision of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.
Philip J LawDivision of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.
Kimmo PalinGenome-Scale Biology Research Program, Research Programs Unit Department of Medical and Clinical Genetics, Medicum.
Sari TuupanenGenome-Scale Biology Research Program, Research Programs Unit Department of Medical and Clinical Genetics, Medicum.
Alexandra GylfeGenome-Scale Biology Research Program, Research Programs Unit Department of Medical and Clinical Genetics, Medicum.
Ulrika A HänninenGenome-Scale Biology Research Program, Research Programs Unit Department of Medical and Clinical Genetics, Medicum.
Tatiana CajusoGenome-Scale Biology Research Program, Research Programs Unit Department of Medical and Clinical Genetics, Medicum.
Tomas TanskanenGenome-Scale Biology Research Program, Research Programs Unit Department of Medical and Clinical Genetics, Medicum.
Johanna KondelinGenome-Scale Biology Research Program, Research Programs Unit Department of Medical and Clinical Genetics, Medicum.
Eevi KaasinenGenome-Scale Biology Research Program, Research Programs Unit Department of Medical and Clinical Genetics, Medicum.
Antti-Pekka SarinInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland.
Jaakko KaprioInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland National Institute for Health and Welfare, Helsinki 00271, Finland.
Johan G ErikssonFolkhälsan Research Centre, Helsinki 00250, Finland Unit of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki 00014, Finland.
Harri RissanenNational Institute for Health and Welfare, Helsinki 00271, Finland.
Paul KnektNational Institute for Health and Welfare, Helsinki 00271, Finland.
Eero PukkalaFinnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki 00130, Finland School of Health Sciences, University of Tampere, Tampere 33014, Finland.
Pekka JousilahtiNational Institute for Health and Welfare, Helsinki 00271, Finland.
Veikko SalomaaNational Institute for Health and Welfare, Helsinki 00271, Finland.
Samuli RipattiInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland.
Aarno PalotieInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Heikki JärvinenDepartment of Surgery, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Helsinki 00029, Finland.
Laura Renkonen-SinisaloDepartment of Surgery, Abdominal Center, Helsinki University Hospital, Helsinki 00029, Finland.
Anna LepistöDepartment of Surgery, Abdominal Center, Helsinki University Hospital, Helsinki 00029, Finland.
Jan BöhmDepartment of Pathology, Central Finland Central Hospital, Jyväskylä 40620, Finland.
Jukka-Pekka MecklinDepartment of Surgery, Jyväskylä Central Hospital, University of Eastern Finland, Jyväskylä 40620, Finland.
Nada A Al-TassanDepartment of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh 12713, Saudi Arabia.
Claire PallesWellcome Trust Centre for Human Genetics and NIHR Comprehensive Biomedical Research Centre, Oxford OX3 7BN, UK.
Lynn MartinWellcome Trust Centre for Human Genetics and NIHR Comprehensive Biomedical Research Centre, Oxford OX3 7BN, UK.
Ella BarclayWellcome Trust Centre for Human Genetics and NIHR Comprehensive Biomedical Research Centre, Oxford OX3 7BN, UK.
Albert TenesaColon Cancer Genetics Group, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK The Roslin Institute, University of Edinburgh, Easter Bush, Roslin EH25 9RG, UK.
Susan FarringtonColon Cancer Genetics Group, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK.
Maria N TimofeevaColon Cancer Genetics Group, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK.
Brian F MeyerDepartment of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh 12713, Saudi Arabia.
Salma M WakilDepartment of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh 12713, Saudi Arabia.
Harry CampbellCentre for Population Health Sciences, University of Edinburgh, Edinburgh EH8 9AG, UK.
Christopher G SmithInstitute of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Shelley IdziaszczykInstitute of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Timothy S MaughanCRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford OX3 7DQ, UK.
Richard KaplanMRC Clinical Trials Unit, Aviation House, London WC2B 6NH, UK.
Rachel KerrDepartment of Oncology, Oxford Cancer Centre, Churchill Hospital.
David KerrNuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 7LE, UK.
Daniel D BuchananColorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Vic. 3010, Australia.
Aung Ko WinCentre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Vic. 3010, Australia.
John HopperCentre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Vic. 3010, Australia.
Mark JenkinsCentre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Vic. 3010, Australia.
Noralane M LindorDepartment of Health Sciences Research, Mayo Clinic, Scottsdale, AZ 85259, USA.
Polly A NewcombCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Steve GallingerLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
David ContiDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Fred SchumacherDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Graham CaseyDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Jussi TaipaleGenome-Scale Biology Research Program, Research Programs Unit Department of Medical and Clinical Genetics, Medicum Department of Biosciences and Nutrition, SciLife Center, Karolinska Institute, Stockholm, SE 141 83, Sweden.
Jeremy P CheadleGenome-Scale Biology Research Program, Research Programs Unit Genome-Scale Biology Research Program, Research Programs Unit.
Malcolm G DunlopColon Cancer Genetics Group, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK.
Ian P TomlinsonWellcome Trust Centre for Human Genetics and NIHR Comprehensive Biomedical Research Centre, Oxford OX3 7BN, UK.
Lauri A AaltonenGenome-Scale Biology Research Program, Research Programs Unit Department of Medical and Clinical Genetics, Medicum.
Richard S HoulstonDivision of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK richard.houlston@icr.ac.uk.
Reaction Biology (Germany) · DECentre for Human Genetics · GBFinnish Institute for Health and Welfare · FIUniversity of Melbourne · AUHelsinki University Hospital · FIInstitute of Cancer Research · GBKing Faisal Specialist Hospital & Research Centre · SAUniversity of Edinburgh · GBUniversity of Helsinki · FIUniversity of Southern California · USCardiff University · GBUniversity of Oxford · GBWestern General Hospital · GBCentral Finland Health Care District · FIChurchill Hospital · GBFred Hutch Cancer Center · USHospital District of Helsinki and Uusimaa · FIInstitute for Molecular Medicine Finland · FIKarolinska Institutet · SEMayo Clinic in Arizona · US

Funding

CALIFORNIA COORDINATED CANCER PREVENTION & CONTROL PROGRAMU58DP003862 · DP · CALIFORNIA STATE DEPT OF PUBLIC HEALTH · PI SNIPES, KURT P · 2012 to 2014
$31.5M
USC Consortium:Colorectal Cancer Family RegistryU01CA074799 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAILE, ROBERT WILLIAM · 1997 to 2008
$20.4M
SEATTLE FAMILIAL COLORECTAL CANCER REGISTRYU01CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 1997 to 2007
$14.1M
ONTARIO REGISTRY FOR STUDIES OF FAMILIAL COLON CANCERU01CA074783 · NCI · CANCER CARE ONTARIO · PI GALLINGER, STEVEN · 1997 to 2008
$12.5M
Colon Cancer Family Registry CohortUM1CA167551 · NCI · STANFORD UNIVERSITY · PI HAILE, ROBERT WILLIAM, JENKINS, MARK A · 2013 to 2017
$11.3M
FAMILIAL COLORECTAL NEOPLASIA COLLABORATIVE GROUPU01CA074800 · NCI · MAYO CLINIC ROCHESTER · PI LINDOR, NORALANE MOREY · 1997 to 2007
$9.1M
Inherited colorectal cancer risk variants: from association to biologyR01CA143237 · NCI · UNIVERSITY OF VIRGINIA · PI CASEY, GRAHAM · 2010 to 2020
$8.4M
The Colon Cancer Family Registry: USC ConsortiumU24CA074799 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAILE, ROBERT WILLIAM · 2008 to 2011
$7.6M
Genomic Wide Association Study of Colorectal CancerU01CA122839 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CASEY, GRAHAM · 2006 to 2010
$7.3M
The Colon Cancer Family Registry: SeattleU24CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 2008 to 2011
$7.0M
AUSTRALASIAN COLORECTAL CANCER FAMILY REGISTRYU01CA097735 · NCI · UNIVERSITY OF MELBOURNE · PI HOPPER, JOHN L · 2002 to 2007
$6.9M
The Colon Cancer Family Registry: AustralasiaU24CA097735 · NCI · UNIVERSITY OF MELBOURNE · PI HOPPER, JOHN L · 2008 to 2011
$6.2M
Cancer Research UK 12076Cancer Research UK 13154Cancer Research UK 15116Cancer Research UK 16459Cancer Research UK 18927Cancer Research UK 20240CCR NIH HHS HHSN261201300011CMedical Research Council G1001799Medical Research Council MC_PC_U127527198Medical Research Council MC_U122861325Medical Research Council MC_U127527198Medical Research Council MC_UU_12023/20Medical Research Council MC_UU_12023/3Medical Research Council MR/K014781/1Medical Research Council MR/K018647/1Medical Research Council MR/N01104X/1NCCDPHP CDC HHS U58 DP003862NCI NIH HHS HHSN261201000034CNCI NIH HHS HHSN261201000035CNCI NIH HHS HHSN261201000035INCI NIH HHS HHSN261201000121CNCI NIH HHS HHSN261201300009CNCI NIH HHS HHSN261201300012INCI NIH HHS HHSN261201300021CNCI NIH HHS K05 CA152715NCI NIH HHS N01 CN067009NCI NIH HHS N01 PC035137NCI NIH HHS N01 PC035142NCI NIH HHS R01 CA143237NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA074794NCI NIH HHS U01 CA074799NCI NIH HHS U01 CA074800NCI NIH HHS U01 CA074806NCI NIH HHS U01 CA097735NCI NIH HHS U01 CA122839NCI NIH HHS U24 CA074783NCI NIH HHS U24 CA074794NCI NIH HHS U24 CA074799NCI NIH HHS U24 CA074800NCI NIH HHS U24 CA074806NCI NIH HHS U24 CA097735NCI NIH HHS UM1 CA167551NIAAA NIH HHS K02 AA018755NIAAA NIH HHS K05 AA000145NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R37 AA012502Wellcome Trust
6 · The paper itself

Abstract

To identify new risk loci for colorectal cancer (CRC), we conducted a meta-analysis of seven genome-wide association studies (GWAS) with independent replication, totalling 13 656 CRC cases and 21 667 controls of European ancestry. The combined analysis identified a new risk association for CRC at 2q35 marked by rs992157 (P = 3.15 × 10

Indexed as

Apoptosis Regulatory ProteinsAsian PeopleColorectal NeoplasmsFemaleGenetic PleiotropyGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansInflammatory Bowel DiseasesLinkage DisequilibriumMaleMembrane ProteinsMuscle ProteinsPolymorphism, Single NucleotideRisk FactorsWhite PeopleApoptosis Regulatory ProteinsMembrane ProteinsMuscle ProteinsPNKD protein, humanTMBIM1 protein, human

Identifiers

PMID27005424
PMCPMC5081051
OpenAlexW2311016709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.