Trial reportSurgical endoscopy2016
Etomidate plus propofol versus propofol alone for sedation during gastroscopy: a randomized prospective clinical trial.
Trial report in Surgical endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Safety and efficacy of combined use of propofol and etomidate for sedation during gastroscopy: Systematic review and meta-analysis.Medicine · 2019Pooled it
- Effect of ciprofol with etomidate on the occurrence of hypotension in elderly patients undergoing upper gastrointestinal endoscopy: a prospective randomized controlled study.BMC anesthesiology · 2026Trial
- Combined Use of Etomidate and Propofol Reduce the Duration of Apnea vs Propofol Alone in Patients Undergoing Hysteroscopy: A Randomised Double-Blind Trial.Drug design, development and therapy · 2026Trial
- Intravenous Anesthesia with Ciprofol and Remimazolam Besylate for Painless Gastroscopy: A Prospective, Single-Center, Randomized Controlled Trial.Drug design, development and therapy · 2025Trial
- Effect of butorphanol on visceral pain in patients undergoing gastrointestinal endoscopy: a randomized controlled trial.BMC anesthesiology · 2023Trial
- Efficacy and safety of propofol target-controlled infusion combined with butorphanol for sedated colonoscopy.World journal of clinical cases · 2023Trial
- Intravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial.Drug design, development and therapy · 2022Trial
- Anesthetic effect of different doses of butorphanol in patients undergoing gastroscopy and colonoscopy.BMC surgery · 2021Trial
- The Efficacy and Safety of Remimazolam Tosilate versus Etomidate-Propofol in Elderly Outpatients Undergoing Colonoscopy: A Prospective, Randomized, Single-Blind, Non-Inferiority Trial.Drug design, development and therapy · 2021Trial
- Etomidate Sedation for Advanced Endoscopic Procedures.Digestive diseases and sciences · 2019Trial
- Trial
- Article
- Effect of Remimazolam versus Propofol Sedation on Postoperative Sleep Quality Following Gastroscopy: A Propensity Score-Matched Cohort Study.Drug design, development and therapy · 2026Article
- Etomidate-propofol combination in painless gastrointestinal endoscopy for elderly patients: A comparative study.World journal of gastrointestinal surgery · 2025Article
- Development and validation of a hypoxemia prediction model in middle-aged and elderly outpatients undergoing painless gastroscopy.Scientific reports · 2025Article
- Behavioral studies of the abuse potential and anesthetic and sedative effects of etomidate in male rodents.Psychopharmacology · 2025Article
- Advances in the Clinical Application of MAC: A Review of Drug Selection, Combination Therapy, and Administration Methods.Drug design, development and therapy · 2025Review
- New sedatives and analgesic drugs for gastrointestinal endoscopic procedures.Clinical endoscopy · 2022Review
- The median effective concentration of propofol in combination with different doses of esketamine during gastrointestinal endoscopy in adults.Frontiers in pharmacology · 2022Article
- Clinical observation of the combined use of propofol and etomidate in painless gastroscopy.Medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsSedation with propofol alone during gastroscopy has many side effects. Etomidate has advantages in terms of circulation and respiration compared to propofol. We hypothesized that etomidate plus propofol during gastroscopy would be more safe and effective than propofol alone.
methodsFour hundred (n = 400) patients were randomly divided into a propofol group (P group) and a etomidate plus propofol group (EP group). The P group was given the first dose of 1 % propofol 1 mg/kg before gastroscopy, and the EP group was given 1 % propofol 0.5 mg/kg plus etomidate 0.1 mg/kg. Repeated doses of 10-20 mg propofol or 5-10 mg propofol plus 1-2 mg etomidate were administered to maintain an adequate level of sedation. The sedation depth was maintained by bispectral index value of 40-60.
resultsThe EP group had a lower incidence of systolic hypotension (13.0 vs. 32.5 %; P < 0.0001), bradycardia (8.5 vs. 16.5 %; P = 0.0226), mild hypoxemia (6.5 vs. 18.0 %; P = 0.0007), and severe hypoxemia (2.5 vs. 10.0 %; P = 0.0031) compared to the P group. Also, the satisfaction of anesthetist and gastroscopist with EP was higher than that of P group (P < 0.0001; P = 0.018, respectively).
conclusionEtomidate plus propofol had few effects on respiration and circulation in patients undergoing gastroscopy and was more safe and effective than propofol alone.
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