Evidence map›Paper›PMID 27005292›Full record

ArticleSurgical endoscopy2016

Hiatal hernia and gastroesophageal reflux: Study of collagen in the phrenoesophageal ligament.

V von Diemen, E N Trindade, M R M Trindade

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05283447 (Effectiveness of Manual Therapy in the Treatment of Gastroesophageal Reflux Disease in Patients With Type I Hiatal Hernia), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05283447 nacompletednot on this mapstarted 2022, after this paper: background citation

Effectiveness of Manual Therapy in the Treatment of Gastroesophageal Reflux Disease in Patients With Type I Hiatal Hernia

TypeinterventionalSponsorEscoles Universitaries GimbernatRan2022 to 2023Enrolled44ConditionsGastroesophageal RefluxArmsOsteopathic Medicine, Control
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Efficacy and safety of mesh reinforced cruroplasty with Phasix™ ST vs. Bio-AHernia : the journal of hernias and abdominal wall surgery · 2026
    Pooled it
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

V von DiemenDigestive Surgery Service, Hospital de Clínicas of Porto Alegre, Ramiro Barcelos, 2350. 7º Floor/Room 743, Porto Alegre, RS, CEP 90035-903, Brazil. viniciusvon@hotmail.com.ORCID 0000-0002-0291-2260
E N TrindadeDigestive Surgery Service, Hospital de Clínicas of Porto Alegre, Ramiro Barcelos, 2350. 7º Floor/Room 743, Porto Alegre, RS, CEP 90035-903, Brazil.
M R M TrindadeDepartment of Surgery, Federal University of Rio Grande do Sul, Ramiro Barcelos, 2400, Porto Alegre, Rio Grande do Sul, Brazil.
Hospital de Clínicas de Porto Alegre · BRUniversidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastroesophageal reflux disease (GERD) is defined by the intensity and/or quality of the reflux of gastric or duodenal contents into the esophagus. Surgical treatment of GERD has shown conflicting results and unacceptable recurrence rates, mainly due to herniation of the antireflux valve into the chest. A variety of techniques has been proposed to reduce GERD recurrence, including routine use of prosthesis in cruroplasty. The prevalence of GERD in patients with hiatal hernia (HH) can reach 94 %. It is possible that the phrenoesophageal ligament (POL) engaged in the stabilization of the gastroesophageal junction in the abdomen may be an etiological factor of HH. We conducted a study to evaluate collagen in the constitution of the POL in patients with HH and cadavers without HH.

methodsPOL samples were collected from 29 patients with HH and GERD (cases) and 32 samples from cadavers without HH (controls). Total collagen was quantified through the Picrosirius red histochemical technique, and type-I and type-III collagens were quantified immunohistochemically using a monoclonal antibody. The stained slides were photographed, and images were quantified by computer software (Image Pro Plus) to count the pixels per field.

resultsThe mean age was 49.5 (±11.5) years for the cases and 38.5 (±13) years for the controls (p < 0.01). Seventeen cases (58.6 %) and six controls (18.75 %) were female (p < 0.01). The quantity of total (p < 0.01), type-I (p < 0.01), and type-III (p < 0.05) collagens was significantly lower by about 60 % in patients with HH compared with controls.

conclusionOur data indicate that the composition of POL for patients with GERD and HH includes less total, type-I, and type-III collagens than that of the POL of cadavers without HH. The quality of the POL may be an etiological factor in the development of HH.

Indexed as

AdultCase-Control StudiesCollagen Type IIIEsophagogastric JunctionFemaleGastroesophageal RefluxHernia, HiatalHumansLaparoscopyLigamentsMaleMiddle AgedCollagen Type IIICollagenGastroesophageal reflux diseaseHiatal herniaPhrenoesophageal ligament

Identifiers

PMID27005292
OpenAlexW2311818388

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.