ArticleCancer research and treatment2016
Radiation-Induced Sarcoma: A 15-Year Experience in a Single Large Tertiary Referral Center.
Article in Cancer research and treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Radiation-Induced Sarcomas of the Head and Neck: A Systematic Review.Advances in therapy · 2021Pooled it
- The Diagnostic Trap in Radiation-Induced Mesothelioma: Kinetic-Morphological Decoupling Masks Molecular Aggression.Cancers · 2026Article
- Postoperative radiotherapy-induced pulmonary leiomyosarcoma in breast cancer: a case report and literature review.Frontiers in oncology · 2026Article
- A retrospective study of post-radiation sarcoma from three institutions in Japan with a review of the literature.Nagoya journal of medical science · 2025Article
- Imaging in sensorineural and conductive hearing loss-an educational review.La Radiologia medica · 2025Review
- A bone tumor-like chest wall mass lesion with pathological rib fractures observed 13 years after lung stereotactic body radiotherapy: A case report.Thoracic cancer · 2024Article
- Review
- Clinico-demographic characteristics and outcomes of radiation-induced sarcomas (RIS): a CanSaRCC study.Therapeutic advances in medical oncology · 2023Article
- Histology-Specific Prognostication for Radiation-Associated Soft Tissue Sarcoma.JCO precision oncology · 2022Article
- Premalignant Conditions of Bone.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2022Article
- Radiation-induced osteosarcoma in the pubic bone after proton radiotherapy for prostate cancer: a case report.Journal of rural medicine : JRM · 2022Article
- Pelvic Radiation-Induced Sarcoma With Rhabdomyoblastic Differentiation Following Treatment of Cervical Cancer.Cureus · 2021Article
- Proliferating trichilemmal tumour of the eyelid in a 7-year-old girl.BMJ case reports · 2021Article
- Prognostic Score-Based Stratification Analysis Reveals Universal Benefits of Radiotherapy on Lowering the Risk of Ipsilateral Breast Event for Ductal Carcinoma In Situ Patients with Different Risk Levels.Annals of surgical oncology · 2021Article
- Incidence of radiation induced sarcoma attributable to radiotherapy in adults: A retrospective cohort study in the SEER cancer registries across 17 primary tumor sites.Cancer epidemiology · 2021Article
- Osteosarcoma of the jaw - experience at the Medical University Vienna and comparative study with international tumor registries.Clinics (Sao Paulo, Brazil) · 2019Article
- Unique Case Report of a Meningeal Sarcoma Arising during Ongoing Treatment for Progressing Intraparenchymal Glioma.Case reports in oncological medicine · 2019Article
- Radiation-associated sarcoma after breast cancer in a nationwide population: Increasing risk of angiosarcoma.Cancer medicine · 2018Article
- Radiation-induced osteosarcoma of the maxilla and mandible after radiotherapy for nasopharyngeal carcinoma.Chinese journal of cancer · 2016Article
- Radiation-induced sarcoma in a cat following hypofractionated, palliative intent radiation therapy for large-cell lymphoma.JFMS open reportsArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study is to report on the incidence and the experience in management of radiation-induced sarcoma (RIS) at a large single center in Korea for 15 years. MATERIALS AND
methodsWe retrospectively reviewed the sarcoma registry of a large institution from January 2000 to April 2014.
resultsOut of the 3,674 patients listed in the registry, 33 patients (0.9%) diagnosed with RIS were identified. The median latency of RIS was 12.1 years. The number of cases of RIS increased from four cases in the years 2000-2003 to 14 cases in the years 2012-2014. The most common histology was osteosarcoma (36.4%). The median follow-up period was 23.1 months, the median overall survival (OS) of all patients was 2.9 years, and their 5-year survival rate was 44.7%. Univariate and multivariate analyses showed association of the age at diagnosis (p=0.01) and the treatment aim (p=0.001) with the OS. The median OS and the 5-year survival rate of patients treated with curative surgery (n=19) were 9.6 years and 65%, respectively, and of the conservatively treated patients, 0.7 years and 0% (n=14). Re-irradiation was delivered to nine patients, and radiation toxicity was observed in five patients.
conclusionIn this study, RIS accounted for 0.9% of the cases of sarcoma, with increasing incidence. Despite the association of curative resection with increased survival, it could be applied to only 58% of the patients. Considering the limited treatment options for RIS, conduct of a genetic study to identify the underlying mechanism of RIS is needed.
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