ArticleAsian-Australasian journal of animal sciences2016
Dietary Niacin Supplementation Suppressed Hepatic Lipid Accumulation in Rabbits.
Article in Asian-Australasian journal of animal sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Lecithin supplementation to HFD improves largemouth bass liver health: Implications for regulating lipid homeostasis, antioxidant responses and endoplasmic reticulum stress.Fish physiology and biochemistry · 2026Article
- Proteomic Analysis of Protein Ubiquitination Events in Dairy Goats with Fatty Liver.Animals : an open access journal from MDPI · 2025Article
- Review
- Mechanistic target of rapamycin and an extracellular signaling-regulated kinases 1 and 2 signaling participate in the process of acetate regulating lipid metabolism and hormone-sensitive lipase expression.Animal bioscience · 2022Article
- Higher niacin intakes improve the lean meat rate of Ningxiang pigs by regulating lipid metabolism and gut microbiota.Frontiers in nutrition · 2022Article
- Protein acetylation in mitochondria plays critical functions in the pathogenesis of fatty liver disease.BMC genomics · 2020Article
- Identification of Crucial Genetic Factors, Such as PPARγ, that Regulate the Pathogenesis of Fatty Liver Disease in Dairy Cows Is Imperative for the Sustainable Development of Dairy Industry.Animals : an open access journal from MDPI · 2020Review
- Acetate Affects the Process of Lipid Metabolism in Rabbit Liver, Skeletal Muscle and Adipose Tissue.Animals : an open access journal from MDPI · 2019Article
- Effect of dietary copper addition on lipid metabolism in rabbits.Food & nutrition research · 2017Article
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4 authors at 1 institution in 1 country.
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Abstract
An experiment was conducted to investigate the effect of niacin supplementation on hepatic lipid metabolism in rabbits. Rex Rabbits (90 d, n = 32) were allocated to two equal treatment groups: Fed basal diet (control) or fed basal diet with additional 200 mg/kg niacin supplementation (niacin). The results show that niacin significantly increased the levels of plasma adiponectin, hepatic apoprotein B and hepatic leptin receptors mRNA (p<0.05), but significantly decreased the hepatic fatty acid synthase activity and adiponectin receptor 2, insulin receptor and acetyl-CoA carboxylase mRNA levels (p<0.05). Plasma insulin had a decreasing tendency in the niacin treatment group compared with control (p = 0.067). Plasma very low density lipoproteins, leptin levels and the hepatic adiponectin receptor 1 and carnitine palmitoyl transferase 1 genes expression were not significantly altered with niacin addition to the diet (p>0.05). However, niacin treatment significantly inhibited the hepatocytes lipid accumulation compared with the control group (p<0.05). In conclusion, niacin treatment can decrease hepatic fatty acids synthesis, but does not alter fatty acids oxidation and triacylglycerol export. And this whole process attenuates lipid accumulation in liver. Besides, the hormones of insulin, leptin and adiponectin are associated with the regulation of niacin in hepatic lipid metabolism in rabbits.
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