ArticleNeuropsychologia2016
Altered striatal intrinsic functional connectivity in pediatric anxiety.
Article in Neuropsychologia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A systematic review and meta-analysis of resting-state fMRI in anxiety disorders: Need for data sharing to move the field forward.Journal of anxiety disorders · 2023Pooled it
- Neurochemical Alterations in Social Anxiety Disorder (SAD): A Systematic Review of Proton Magnetic Resonance Spectroscopic Studies.International journal of molecular sciences · 2022Pooled it
- Resting-state neuroimaging in social anxiety disorder: a systematic review.Molecular psychiatry · 2022Pooled it
- Subcortical resting state functional connectivity as a neural marker of first onset internalizing disorder in high-risk youth.Neuroimage. Reports · 2025Article
- A Proton Magnetic Resonance Spectroscopy (International journal of molecular sciences · 2025Article
- Functional Connectivity of the Nucleus Accumbens across Variants of Callous-Unemotional Traits: A Resting-State fMRI Study in Children and Adolescents.Research on child and adolescent psychopathology · 2024Article
- Associations of observed preschool performance monitoring with brain functional connectivity in adolescence.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Reduced neural differentiation of rewards and punishment during passive avoidance learning in adolescents with generalized anxiety disorder.Depression and anxiety · 2021Article
- Adolescent anxiety disorders and the developing brain: comparing neuroimaging findings in adolescents and adults.General psychiatry · 2021Review
- MRI Insights Into Adolescent Neurocircuitry-A Vision for the Future.Frontiers in human neuroscience · 2020Article
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Authors and funding
5 authors.
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Abstract
Anxiety disorders are among the most common psychiatric disorders of adolescence. Behavioral and task-based imaging studies implicate altered reward system function, including striatal dysfunction, in adolescent anxiety. However, no study has yet examined alterations of the striatal intrinsic functional connectivity in adolescent anxiety disorders. The current study examines striatal intrinsic functional connectivity (iFC), using six bilateral striatal seeds, among 35 adolescents with anxiety disorders and 36 healthy comparisons. Anxiety is associated with abnormally low iFC within the striatum (e.g., between nucleus accumbens and caudate nucleus), and between the striatum and prefrontal regions, including subgenual anterior cingulate cortex, posterior insula and supplementary motor area. The current findings extend prior behavioral and task-based imaging research, and provide novel data implicating decreased striatal iFC in adolescent anxiety. Alterations of striatal neurocircuitry identified in this study may contribute to the perturbations in the processing of motivational, emotional, interoceptive, and motor information seen in pediatric anxiety disorders. This pattern of the striatal iFC perturbations can guide future research on specific mechanisms underlying anxiety.
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