ArticleNature communications2016
Rotational manipulation of single cells and organisms using acoustic waves.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 160 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
160 citing papers in PubMed, 483 citations in OpenAlex.
- Ultrasound-driven electronically programmable microbubbles.Science advances · 2026Article
- Acoustically driven micro/nanobubbles: from fundamental mechanisms to biomedical applications.Microsystems & nanoengineering · 2026Review
- Microbubble-free mechanical sonoporation for MR-guided drug delivery in solid tumours: a proof-of-concept study.Drug delivery and translational research · 2026Article
- Acoustofluidic cryo-EM enables in situ particle manipulation for uniform, high-quality cryo-EM specimens.Science advances · 2026Article
- On-demand rotational manipulation of microparticles and zebrafish larvae via orthogonally phased BAW acoustofluidics.Microsystems & nanoengineering · 2026Article
- Programmable rotation of single cells along arbitrary axes via opto-thermo-osmotic torque.Light, science & applications · 2026Article
- Tunable acoustic rotation for deep biophysical phenotyping of preclinical Alzheimer's disease.Materials today. Bio · 2026Article
- Helical opto-thermoviscous flows drive out-of-plane rotation and particle spinning in a highly viscous micro-environment.Light, science & applications · 2026Article
- Space-time acoustofluidic tweezers for dynamic and selective manipulation of microparticles.Science advances · 2026Article
- Advances in Strategies for Colloidal Self-Assembly.Chemical reviews · 2026Review
- Nanorobotic Approaches Against Multidrug-Resistant Infections: Design, Principle, Mechanistic Innovation, Translational Challenges and Biomedical Applications.Molecules (Basel, Switzerland) · 2026Review
- A Programmable and Portable Electromagnetic Microfluidic Platform for Droplet Manipulation.Biosensors · 2026Article
- Tunable 3D optohydrodynamic torques from optical phase gradient-driven colloidal assemblies.Science advances · 2026Article
- Acoustic Bubble Sensing Techniques and Bioapplications.Biosensors · 2026Review
- Precision acoustofluidics for high-throughput mechanobiology in suspension cells.Science advances · 2026Article
- Lab on an end: Micromanipulation using the acoustohydrodynamic pillar array as an end effector.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Programmable acoustofluidic engineering for creating gradient biomaterials.Science advances · 2025Article
- Electrostatics overcome acoustic collapse to assemble, adapt, and activate levitated matter.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Scaling Effects on Single-Cell Manipulation Using Magnetic Forces at Edge of Flat Plate With Elliptically Micro-Projection.Biotechnology and bioengineering · 2025Article
- HarnessingSensors (Basel, Switzerland) · 2025Review
100 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The precise rotational manipulation of single cells or organisms is invaluable to many applications in biology, chemistry, physics and medicine. In this article, we describe an acoustic-based, on-chip manipulation method that can rotate single microparticles, cells and organisms. To achieve this, we trapped microbubbles within predefined sidewall microcavities inside a microchannel. In an acoustic field, trapped microbubbles were driven into oscillatory motion generating steady microvortices which were utilized to precisely rotate colloids, cells and entire organisms (that is, C. elegans). We have tested the capabilities of our method by analysing reproductive system pathologies and nervous system morphology in C. elegans. Using our device, we revealed the underlying abnormal cell fusion causing defective vulval morphology in mutant worms. Our acoustofluidic rotational manipulation (ARM) technique is an easy-to-use, compact, and biocompatible method, permitting rotation regardless of optical, magnetic or electrical properties of the sample under investigation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.