ArticleThe Journal of pediatrics2016
High Flow Nasal Cannula Use Is Associated with Increased Morbidity and Length of Hospitalization in Extremely Low Birth Weight Infants.
Article in The Journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Can high-flow nasal cannula reduce the risk of bronchopulmonary dysplasia compared with CPAP in preterm infants? A systematic review and meta-analysis.BMC pediatrics · 2021Pooled it
- Physiological effects of high-flow nasal cannula therapy in preterm infants.Archives of disease in childhood. Fetal and neonatal edition · 2020Trial
- Duration of continuous positive airway pressure: associations with length of stay and oral feeding patterns in a level IV neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
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- Article
- Respiratory support and bronchopulmonary dysplasia in infants born at 22-26 weeks gestation in Sweden, 2004-2007 and 2014-2016.The European respiratory journal · 2025Article
- Feasibility and safety of weaning premature infants from nasal continuous positive airway pressure to high-flow nasal cannula: a prospective observational case study.BMC pediatrics · 2024Observational
- Improved survival at the cost of more chronic lung disease? Current management and outcomes in extremely preterm infants born in New South Wales and the Australian Capital Territory: 2010-2020.World journal of pediatrics : WJP · 2024Article
- Changes in the patterns of respiratory support and incidence of bronchopulmonary dysplasia; a single center experience.BMC pediatrics · 2023Article
- Noninvasive Ventilation in Preterm Infants: Factors Influencing Weaning Decisions and the Role of the Silverman-Andersen Score.Children (Basel, Switzerland) · 2022Article
- Ventilation and respiratory outcome in extremely preterm infants: trends in the new millennium.European journal of pediatrics · 2022Article
- Treatment of Pediatric Patients With High-Flow Nasal Cannula and Considerations for Oral Feeding: A Review of the Literature.Perspectives of the ASHA special interest groups · 2022Article
- Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Analysis of risk factors for the failure of respiratory support with high-flow nasal cannula oxygen therapy in children with acute respiratory dysfunction: A case-control study.Frontiers in pediatrics · 2022Article
- Life-threatening bronchopulmonary dysplasia: a British Paediatric Surveillance Unit Study.Archives of disease in childhood. Fetal and neonatal edition · 2022Observational
- Birth during on-call period: Impact of care organization on mortality and morbidity of very premature neonates.Frontiers in pediatrics · 2022Article
- Non-Invasive Ventilatory Strategies to Decrease Bronchopulmonary Dysplasia-Where Are We in 2021?Children (Basel, Switzerland) · 2021Review
- Oral-feeding guidelines for preterm neonates in the NICU: a scoping review.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Non-invasive Respiratory Support of the Premature Neonate: From Physics to Bench to Practice.Frontiers in pediatrics · 2020Review
- A Review on Non-invasive Respiratory Support for Management of Respiratory Distress in Extremely Preterm Infants.Frontiers in pediatrics · 2020Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo determine differences in the incidence of bronchopulmonary dysplasia (BPD) or death in extremely low birth weight infants managed on high flow nasal cannula (HFNC) vs continuous positive airway pressure (CPAP). STUDY
designThis is a retrospective data analysis from the Alere Neonatal Database for infants born between January 2008 and July 2013, weighing ≤1000 g at birth, and received HFNC or CPAP. Baseline demographics, clinical characteristics, and neonatal outcomes were compared between the infants who received CPAP and HFNC, or HFNC ± CPAP. Multivariable regression analysis was performed to control for the variables that differ in bivariate analysis.
resultsA total of 2487 infants met the inclusion criteria (941 CPAP group, 333 HFNC group, and 1546 HFNC ± CPAP group). The primary outcome of BPD or death was significantly higher in the HFNC group (56.8%) compared with the CPAP group (50.4%, P < .05). Similarly, adjusted odds of developing BPD or death was greater in the HFNC ± CPAP group compared with the CPAP group (OR 1.085, 95% CI 1.035-1.137, P = .001). The number of ventilator days, postnatal steroid use, days to room air, days to initiate or reach full oral feeds, and length of hospitalization were significantly higher in the HFNC and HFNC ± CPAP groups compared with the CPAP group.
conclusionsIn this retrospective study, use of HFNC in extremely low birth weight infants is associated with a higher risk of death or BPD, increased respiratory morbidities, delayed oral feeding, and prolonged hospitalization. A large clinical trial is needed to evaluate long-term safety and efficacy of HFNC in preterm infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.