ArticleHuman brain mapping2016
Effect of rs1063843 in the CAMKK2 gene on the dorsolateral prefrontal cortex.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- CaMKK2 as an emerging treatment target for bipolar disorder.Molecular psychiatry · 2023Review
- OL-FS13 Alleviates Cerebral Ischemia-reperfusion Injury by Inhibiting miR-21-3p Expression.Current neuropharmacology · 2023Article
- Evidence for the contribution of HCN1 gene polymorphism (rs1501357) to working memory at both behavioral and neural levels in schizophrenia patients and healthy controls.Schizophrenia (Heidelberg, Germany) · 2022Article
- Associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia-related structural and functional brain changes.Frontiers in genetics · 2022Article
- Article
- From Anti-SARS-CoV-2 Immune Responses to COVID-19 via Molecular Mimicry.Antibodies (Basel, Switzerland) · 2020Article
- What is the optimal neuropsychological test battery for schizophrenia in China?Schizophrenia research · 2019Article
- Polymorphism in schizophrenia risk geneNeuroImage. Clinical · 2018Article
- Effect of rs1344706 in theNeuroImage. Clinical · 2018Article
- An adaptive, individualized fMRI delay discounting procedure to increase flexibility and optimize scanner time.NeuroImage · 2017Article
- Impact of Genetic Variation on Human CaMKK2 Regulation by CaScientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, a single nucleotide polymorphism (SNP) in the CAMKK2 gene (rs1063843) was found to be associated with lower expression of the gene in the dorsolateral prefrontal cortex (DLPFC) and with schizophrenia (SCZ) and deficits in working memory and executive function. However, the brain mechanism underlying this association is poorly understood. A functional magnetic resonance imaging (fMRI) study (N = 84 healthy volunteers) involving multiple cognitive tasks, including a Stroop task (to measure attentional executive control), an N-back task (to measure working memory), and a delay discounting task (to measure decision making) to identify the brain regions affected by rs1063843 was performed. Across all three tasks, it was found that carriers of the risk allele consistently exhibited increased activation of the left DLPFC. In addition, the risk allele carriers also exhibited increased activation of the right DLPFC and the left cerebellum during the Stroop task and of the left caudate nucleus during the N-back task. These findings helped to elucidate the role of CAMKK2 in cognitive functions and in the etiology of SCZ. Hum Brain Mapp 37:2398-2406, 2016. © 2016 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.