ArticleScientific reports2016
Changing pattern in the basal ganglia: motor switching under reduced dopaminergic drive.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Trial
- The chain mediation effects of general self-efficacy and psychological resilience between physical activity and academic stress among Chinese adolescents.Frontiers in psychology · 2025Article
- Grid cells: the missing link in understanding Parkinson's disease?Frontiers in neuroscience · 2024Article
- Toward Personalized Deep Brain Stimulation for Obsessive-Compulsive Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Deep brain stimulation for movement disorder treatment: exploring frequency-dependent efficacy in a computational network model.Biological cybernetics · 2022Article
- A change of mind: Globus pallidus activity and effective connectivity during changes in choice selections.The European journal of neuroscience · 2021Article
- Ancestral regulatory mechanisms specify conserved midbrain circuitry in arthropods and vertebrates.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Variability in Action Selection Relates to Striatal Dopamine 2/3 Receptor Availability in Humans: A PET Neuroimaging Study Using Reinforcement Learning and Active Inference Models.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Value encoding in the globus pallidus: fMRI reveals an interaction effect between reward and dopamine drive.NeuroImage · 2018Article
- Computational Psychiatry of ADHD: Neural Gain Impairments across Marrian Levels of Analysis.Trends in neurosciences · 2016Review
- Evolutionarily conserved mechanisms for the selection and maintenance of behavioural activity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
Abstract
Action selection in the basal ganglia is often described within the framework of a standard model, associating low dopaminergic drive with motor suppression. Whilst powerful, this model does not explain several clinical and experimental data, including varying therapeutic efficacy across movement disorders. We tested the predictions of this model in patients with Parkinson's disease, on and off subthalamic deep brain stimulation (DBS), focussing on adaptive sensory-motor responses to a changing environment and maintenance of an action until it is no longer suitable. Surprisingly, we observed prolonged perseverance under on-stimulation, and high inter-individual variability in terms of the motor selections performed when comparing the two conditions. To account for these data, we revised the standard model exploring its space of parameters and associated motor functions and found that, depending on effective connectivity between external and internal parts of the globus pallidus and saliency of the sensory input, a low dopaminergic drive can result in increased, dysfunctional, motor switching, besides motor suppression. This new framework provides insight into the biophysical mechanisms underlying DBS, allowing a description in terms of alteration of the signal-to-baseline ratio in the indirect pathway, which better account of known electrophysiological data in comparison with the standard model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.