Evidence map›Paper›PMID 27004250›Full record

ArticleEndoscopy international open2016

Volumetric laser endomicroscopy can target neoplasia not detected by conventional endoscopic measures in long segment Barrett's esophagus.

Arvind J Trindade, Benley J George, Joshua Berkowitz, Divyesh V Sejpal, Matthew J McKinley

Registry-linked trialOpen access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Endoscopy international open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03814824 (Volumetric Laser Endomicroscopy With Intelligent Real-time Image Segmentation), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03814824 nacompletednot on this mapstarted 2019, after this paper: background citation

Volumetric Laser Endomicroscopy With Intelligent Real-time Image Segmentation (IRIS): a Multi-center Randomized Prospective Study

TypeinterventionalSponsorNorthwell HealthRan2019 to 2021Enrolled148ConditionsBarrett's Esophagus Without Dysplasia, Barrett's Esophagus With Dysplasia, Barrett's Esophagus With Low Grade Dysplasia, Barrett's Esophagus With High Grade DysplasiaArmsIRIS (Intelligent real-time image segmentation), VLE (Volumetric laser endomicroscopy)
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 31 citations in OpenAlex.

  1. Volumetric laser endomicroscopy and its application to Barrett's esophagus: results from a 1,000 patient registry.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2019
    Observational
  2. Review
  3. Review
  4. Review
  5. Review
  6. Endoscopic diagnosis and treatment of early esophageal squamous neoplasia.World journal of gastrointestinal endoscopy · 2017
    Review
  7. Article
  8. Past, present and future of Barrett's oesophagus.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2017
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Arvind J TrindadeHofstra North Shore-Long Island Jewish School of Medicine, North Shore University Hospital, Manhasset, NY, United States.
Benley J GeorgeHofstra North Shore-Long Island Jewish School of Medicine, North Shore University Hospital, Manhasset, NY, United States.
Joshua BerkowitzHofstra North Shore-Long Island Jewish School of Medicine, North Shore University Hospital, Manhasset, NY, United States.
Divyesh V SejpalHofstra North Shore-Long Island Jewish School of Medicine, North Shore University Hospital, Manhasset, NY, United States.
Matthew J McKinleyHofstra North Shore-Long Island Jewish School of Medicine, North Shore University Hospital, Manhasset, NY, United States.
North Shore University Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methods and study aims: The incidence of esophageal cancer is rising despite increased surveillance efforts. Volumetric laser endomicroscopy (VLE) is a new endoscopic imaging tool that can allow for targeted biopsy of neoplasia in Barrett's esophagus. We report a series of 6 patients with long-segment Barrett's esophagus ( > 3 cm), who underwent a session of endoscopy with volumetric laser endomicroscopy, after a separate prior session of standard high-definition endoscopy with narrow band imaging (NBI) and random biopsies that did not reveal neoplasia. In all six patients, the first endoscopy was the index endoscopy diagnosing the Barrett's esophagus. All VLE exams were performed within 6 months of the previous endoscopy. In five patients, VLE-targeted biopsy resulted in upstaged disease/diagnosed dysplasia that then qualified the patient for endoscopic ablation therapy. In one patient, VLE localized a focus of intramucosal cancer that allowed for curative endoscopic mucosal resection. This case series shows that endoscopy with VLE can target neoplasia that cannot be localized by high-definition endoscopy with NBI and random biopsies.

Identifiers

PMID27004250
PMCPMC4798840
OpenAlexW2298015525

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.