Evidence map›Paper›PMID 27003900›Full record

ArticleLipids2016

Increased Serum Level of Cyclopropaneoctanoic Acid 2-Hexyl in Patients with Hypertriglyceridemia-Related Disorders.

Adriana Mika, Piotr Stepnowski, Michal Chmielewski, Sylwia Malgorzewicz, Lukasz Kaska, Monika Proczko, Krzysztof Ratnicki-Sklucki, Maciej Sledzinski, Tomasz Sledzinski

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03612700 (Presence of Cyclopropane Fatty Acids), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03612700 nacompletednot on this mapstarted 2018, after this paper: background citation

Presence of Cyclopropane Fatty Acids (CPFA) in Human Plasma After CPFA-rich Diet

TypeinterventionalSponsorUniversity of ParmaRan2018 to 2018Enrolled10ConditionsBiological AvailabilityArmsCPFA-rich foods
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Adriana MikaDepartment of Environmental Analysis, Faculty of Chemistry, University of Gdansk, 63 Wita Stwosza Str., 80-308, Gdansk, Poland.
Piotr StepnowskiDepartment of Environmental Analysis, Faculty of Chemistry, University of Gdansk, 63 Wita Stwosza Str., 80-308, Gdansk, Poland.
Michal ChmielewskiDepartment of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, 7 Debinki Str., 80-952, Gdansk, Poland.
Sylwia MalgorzewiczDepartment of Clinical Nutrition, Medical University of Gdansk, 7 Debinki Str., 80-952, Gdansk, Poland.
Lukasz KaskaDepartment of General, Endocrine and Transplant Surgery, Medical University of Gdansk, 17 Smoluchowskiego Str., 80-214, Gdansk, Poland.
Monika ProczkoDepartment of General, Endocrine and Transplant Surgery, Medical University of Gdansk, 17 Smoluchowskiego Str., 80-214, Gdansk, Poland.
Krzysztof Ratnicki-SkluckiDepartment of General, Endocrine and Transplant Surgery, Medical University of Gdansk, 17 Smoluchowskiego Str., 80-214, Gdansk, Poland.
Maciej SledzinskiDepartment of Emergency Medicine, Medical University of Gdansk, 17 Smoluchowskiego Str., 80-214, Gdansk, Poland.
Tomasz SledzinskiDepartment of Pharmaceutical Biochemistry, Medical University of Gdansk, 1 Dębinki Str., 80-211, Gdansk, Poland. tsledz@gumed.edu.pl.
Gdańsk Medical University · PLUniversity of Gdańsk · PLWeatherford College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We recently reported the presence of various cyclopropane fatty acids-among them, cyclopropaneoctanoic acid 2-hexyl-in the adipose tissue of obese women. The aim of this study was to verify whether the presence of cyclopropaneoctanoic acid 2-hexyl in human serum was associated with obesity or chronic kidney disease (both being related to dyslipidemia), and to find potential associations between the serum level of this compound and specific markers of the these conditions. The serum concentration of cyclopropaneoctanoic acid 2-hexyl was determined by gas chromatography-mass spectrometry (GC-MS) in non-obese controls, obese patients, obese patients after a 3-month low-calorie diet, and individuals with chronic kidney disease. Obese patients and those with chronic kidney disease presented with higher serum levels of cyclopropaneoctanoic acid 2-hexyl than controls. Switching obese individuals to a low-calorie (low-lipid) diet resulted in a reduction in this fatty acid concentration to the level observed in controls. Cyclopropaneoctanoic acid 2-hexyl was also found in foods derived from animal fat. Serum concentrations of triacylglycerols in the analyzed groups followed a pattern similar to that for serum cyclopropaneoctanoic acid 2-hexyl, and these variables were positively correlated with each other among the studied groups. Patients with hypertriglyceridemia-related conditions presented with elevated serum levels of cyclopropaneoctanoic acid 2-hexyl. Our findings suggest that its high serum level is related to high serum triacylglycerol concentrations rather than to body mass or BMI.

Indexed as

Adipose TissueAdultBody Mass IndexCaloric RestrictionCyclopropanesFatty AcidsFemaleGas Chromatography-Mass SpectrometryHumansHypertriglyceridemiaMiddle AgedObesityRenal Insufficiency, ChronicTriglyceridesYoung Adultcyclopropane fatty acidsCyclopropanesFatty AcidsTriglyceridesChronic kidney diseaseCyclopropaneoctanoic acid 2-hexylHypertriglyceridemiaObesity

Identifiers

PMID27003900
PMCPMC4903102
OpenAlexW2305283360

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.