ArticlePloS one2016
Emotion Regulation and Excess Weight: Impaired Affective Processing Characterized by Dysfunctional Insula Activation and Connectivity.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The influence of stress on the neural underpinnings of disinhibited eating: a systematic review and future directions for research.Reviews in endocrine & metabolic disorders · 2023Pooled it
- Alterations in reward network functional connectivity are associated with increased food addiction in obese individuals.Scientific reports · 2021Trial
- Obesity and Insulin Resistance Alter Neural Processing of Unpleasant, but Not Pleasant, Visual Stimuli in Young Adults.Brain sciences · 2025Article
- The Interplay Between Psychological and Neurobiological Predictors of Weight Regain: A Narrative Review.Nutrients · 2025Review
- Nothing to lose? Neural correlates of decision, anticipation, and feedback in the balloon analog risk task.Psychophysiology · 2024Article
- Non-additive effects of electrical stimulation of the dorsolateral prefrontal cortex and the vestibular system on muscle sympathetic nerve activity in humans.Experimental brain research · 2024Article
- Body mass, neuro-hormonal stress processing, and disease activity in lean to obese people with multiple sclerosis.Journal of neurology · 2024Article
- Top-down control of vestibular inputs by the dorsolateral prefrontal cortex.Experimental brain research · 2023Article
- Dynamic fronto-amygdalar interactions underlying emotion-regulation deficits in women at higher weight.Obesity (Silver Spring, Md.) · 2023Article
- Emotion regulation in bipolar disorder type-I: multivariate analysis of fMRI data.International journal of bipolar disorders · 2023Article
- Psychopathological factors and personality dimensions on dysfunctional eating behaviors in a sample of individuals with obesity.Frontiers in psychology · 2023Article
- Neural Correlates of Reactive Aggression in Adult Attention-Deficit/Hyperactivity Disorder.Frontiers in psychiatry · 2022Article
- Evaluation of altered brain activity in type 2 diabetes using various indices of brain function: A resting-state functional magnetic resonance imaging study.Frontiers in human neuroscience · 2022Article
- The neurobiology of misophonia and implications for novel, neuroscience-driven interventions.Frontiers in neuroscience · 2022Review
- An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2021Article
- Brain Connectivity and Symptom Changes After Transcranial Magnetic Stimulation in Patients With Borderline Personality Disorder.Frontiers in psychiatry · 2021Article
- Reward-related neural correlates in adolescents with excess body weight.NeuroImage. Clinical · 2021Article
- Cerebral glucose metabolism differs according to future weight change.Brain imaging and behavior · 2020Article
- What Difference Does it Make? Risk-Taking Behavior in Obesity after a Loss is Associated with Decreased Ventromedial Prefrontal Cortex Activity.Journal of clinical medicine · 2019Article
- Neuroendocrinological mechanisms underlying impulsive and compulsive behaviors in obesity: a narrative review of fMRI studies.Reviews in endocrine & metabolic disorders · 2019Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emotion-regulation strategies are understood to influence food intake. This study examined the neurophysiological underpinnings of negative emotion processing and emotion regulation in individuals with excess weight compared to normal-weight controls. Fifteen participants with excess-weight (body mass index >25) and sixteen normal-weight controls (body mass index 18-25) performed an emotion-regulation task during functional magnetic resonance imaging. Participants were exposed to 24 negative affective or neutral pictures that they were instructed to Observe (neutral pictures), Maintain (sustain the emotion elicited by negative pictures) or Regulate (down-regulate the emotion provoked by negative pictures through previously trained reappraisal techniques). When instructed to regulate negative emotions by means of cognitive reappraisal, participants with excess weight displayed persistently heightened activation in the right anterior insula. Decreased responsivity was also found in right anterior insula, the orbitofrontal cortex and cerebellum during negative emotion experience in participants with excess weight. Psycho-physiological interaction analyses showed that excess-weight participants had decreased negative functional coupling between the right anterior insula and the right dlPFC, and the bilateral dmPFC during cognitive reappraisal. Our findings support contentions that excess weight is linked to an abnormal pattern of neural activation and connectivity during the experience and regulation of negative emotions, with the insula playing a key role in these alterations. We posit that ineffective regulation of emotional states contributes to the acquisition and preservation of excess weight.
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