ReviewInternational journal of clinical pharmacy2016
Medication safety research by observational study design.
Review in International journal of clinical pharmacy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A Comparison of Active Pharmacovigilance Strategies Used to Monitor Adverse Events to Antiviral Agents: A Systematic Review.Drug safety · 2024Pooled it
- Prevalence and Nature of Medication Errors and Preventable Adverse Drug Events in Paediatric and Neonatal Intensive Care Settings: A Systematic Review.Drug safety · 2019Pooled it
- Pooled it
- Neuropsychiatric outcomes after montelukast versus inhaled corticosteroids in pediatric asthma: a pooled birth cohort study.BMC medicine · 2026Article
- Leveraging Multi-National Observational Study in Post-Marketing Safety Assessment: Challenges and Strategies.Therapeutic innovation & regulatory science · 2025Article
- Evaluating the Potential of Prevalent New User Design as an Alternative When New User Design is Impractical.Pragmatic and observational research · 2025Article
- Artificial Intelligence in Medical Affairs: A New Paradigm with Novel Opportunities.Pharmaceutical medicine · 2024Review
- letter to the editor.Kidney international · 2022Article
- Safety and effectiveness of 4-week therapy with aceclofenac controlled release once a day.Scientific reports · 2022Article
- Cardiovascular events and safety outcomes associated with remdesivir using a World Health Organization international pharmacovigilance database.Clinical and translational science · 2022Article
- A bibliometric analysis of global trends in the research field of pharmaceutical care over the past 20 years.Frontiers in public health · 2022Article
- Methodological frontiers in vaccine safety: qualifying available evidence for rare events, use of distributed data networks to monitor vaccine safety issues, and monitoring the safety of pregnancy interventions.BMJ global health · 2021Review
- Integrated Digital Patient Education at the Bedside for Patients with Chronic Conditions: Observational Study.JMIR mHealth and uHealth · 2020Observational
- Attention-Deficit/Hyperactivity Disorder Medication and Unintentional Injuries in Children and Adolescents.Journal of the American Academy of Child and Adolescent Psychiatry · 2020Article
- Article
- Review
- Critical review of European Medicines Agency (EMA) assessment report and related literature on domperidone.International journal of clinical pharmacy · 2019Review
- Article
- Association of Risk of Suicide Attempts With Methylphenidate Treatment.JAMA psychiatry · 2017Article
- Methylphenidate and the risk of psychotic disorders and hallucinations in children and adolescents in a large health system.Translational psychiatry · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Observational studies have been recognised to be essential for investigating the safety profile of medications. Numerous observational studies have been conducted on the platform of large population databases, which provide adequate sample size and follow-up length to detect infrequent and/or delayed clinical outcomes. Cohort and case-control are well-accepted traditional methodologies for hypothesis testing, while within-individual study designs are developing and evolving, addressing previous known methodological limitations to reduce confounding and bias. Respective examples of observational studies of different study designs using medical databases are shown. Methodology characteristics, study assumptions, strengths and weaknesses of each method are discussed in this review.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.