Evidence map›Paper›PMID 27003703›Full record

ReviewMedicine and science in sports and exercise2016

Neural Contributions to Muscle Fatigue: From the Brain to the Muscle and Back Again.

Janet L Taylor, Markus Amann, Jacques Duchateau, Romain Meeusen, Charles L Rice

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Medicine and science in sports and exercise, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 226 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
226citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

226 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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166 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Janet L Taylor1Neuroscience Research Australia, Sydney, AUSTRALIA; 2School of Medical Sciences, the University of New South Wales, Sydney, AUSTRALIA; 3Department of Medicine, University of Utah, Salt Lake City, UT; 4Laboratory of Applied Biology and Neurophysiology, ULB Neuroscience Institute, Université Libre de Bruxelles, Brussels, BELGIUM; 5Human Physiology Research Group Vrije Universiteit Brussel, Brussels, BELGIUM; 6School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Queensland, AUSTRALIA; and 7School of Kinesiology, and Department of Anatomy and Cell Biology, The University of Western Ontario, London, CANADA.
Markus Amann
Jacques Duchateau
Romain Meeusen
Charles L Rice

Funding

Role of Sensory Neurons in Human Cardiovascular DiseaseR01HL116579 · NHLBI · UNIVERSITY OF UTAH · PI AMANN, MARKUS · 2013 to 2021
$3.4M
Work of Breathing and Oxidative Stress in COPD: Impact on Blood Flow and FatigueR00HL103786 · NHLBI · UNIVERSITY OF UTAH · PI AMANN, MARKUS · 2013 to 2015
$738k
Respiratory muscle work and oxidative stress in COPD: impact on leg blood flow anK99HL103786 · NHLBI · UNIVERSITY OF UTAH · PI AMANN, MARKUS · 2010 to 2011
$161k
Premature fatigue in veterans with heart failure: neuronal influencesI21RX001572 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI AMANN, MARKUS · 2015 to 2016
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NHLBI NIH HHS K99 HL103786NHLBI NIH HHS R00 HL103786NHLBI NIH HHS R01 HL116579RRD VA I21 RX001572
6 · The paper itself

Abstract

: During exercise, there is a progressive reduction in the ability to produce muscle force. Processes within the nervous system as well as within the muscles contribute to this fatigue. In addition to impaired function of the motor system, sensations associated with fatigue and impairment of homeostasis can contribute to the impairment of performance during exercise. This review discusses some of the neural changes that accompany exercise and the development of fatigue. The role of brain monoaminergic neurotransmitter systems in whole-body endurance performance is discussed, particularly with regard to exercise in hot environments. Next, fatigue-related alterations in the neuromuscular pathway are discussed in terms of changes in motor unit firing, motoneuron excitability, and motor cortical excitability. These changes have mostly been investigated during single-limb isometric contractions. Finally, the small-diameter muscle afferents that increase firing with exercise and fatigue are discussed. These afferents have roles in cardiovascular and respiratory responses to exercise, and in the impairment of exercise performance through interaction with the motor pathway, as well as in providing sensations of muscle discomfort. Thus, changes at all levels of the nervous system, including the brain, spinal cord, motor output, sensory input, and autonomic function, occur during exercise and fatigue. The mix of influences and the importance of their contribution vary with the type of exercise being performed.

Indexed as

Body Temperature RegulationBrainFeedback, PhysiologicalHot TemperatureHumansMotor CortexMotor NeuronsMuscle ContractionMuscle FatigueMuscle, SkeletalSynaptic Transmission

Identifiers

PMID27003703
PMCPMC5033663

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.