ArticlePLoS computational biology2016
Noise Expands the Response Range of the Bacillus subtilis Competence Circuit.
Article in PLoS computational biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Mixed positive and negative feedback loops drive diverse single-cell gene expression dynamics.Nature communications · 2026Article
- Cell fate ratios are encoded by transcriptional dynamics in the Drosophila retina.Current biology : CB · 2025Article
- AI-powered simulation-based inference of a genuinely spatial-stochastic gene regulation model of early mouse embryogenesis.PLoS computational biology · 2024Article
- There's Plenty of Room Right Here: Biological Systems as Evolved, Overloaded, Multi-Scale Machines.Biomimetics (Basel, Switzerland) · 2023Article
- Temporally dynamic antagonism between transcription and chromatin compaction controls stochastic photoreceptor specification in flies.Developmental cell · 2022Article
- Different Patterns of mRNA Nuclear Retention during Meiotic Prophase in Larch Microsporocytes.International journal of molecular sciences · 2021Article
- Spiral Wave Propagation in Communities with Spatially Correlated Heterogeneity.Biophysical journal · 2020Article
- Active degradation of MarA controls coordination of its downstream targets.PLoS computational biology · 2018Article
- Buffering and Amplifying Transcriptional Noise During Cell Fate Specification.Frontiers in genetics · 2018Review
- Advances in bacterial cancer therapies using synthetic biology.Current opinion in systems biology · 2017Article
- Customized Regulation of Diverse Stress Response Genes by the Multiple Antibiotic Resistance Activator MarA.PLoS computational biology · 2017Article
- Fitness Trade-Offs in Competence Differentiation of Bacillus subtilis.Frontiers in microbiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Gene regulatory circuits must contend with intrinsic noise that arises due to finite numbers of proteins. While some circuits act to reduce this noise, others appear to exploit it. A striking example is the competence circuit in Bacillus subtilis, which exhibits much larger noise in the duration of its competence events than a synthetically constructed analog that performs the same function. Here, using stochastic modeling and fluorescence microscopy, we show that this larger noise allows cells to exit terminal phenotypic states, which expands the range of stress levels to which cells are responsive and leads to phenotypic heterogeneity at the population level. This is an important example of how noise confers a functional benefit in a genetic decision-making circuit.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.