ArticleJournal of acquired immune deficiency syndromes (1999)2016
FOXP3+Helios+ Regulatory T Cells, Immune Activation, and Advancing Disease in HIV-Infected Children.
Article in Journal of acquired immune deficiency syndromes (1999), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
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Who cites it
22 citing papers in PubMed, 25 citations in OpenAlex.
- Partially-functional exhausted CD8+ T cells can contribute to short-term viral suppression: a computational prediction for children with perinatal HIV.bioRxiv : the preprint server for biology · 2025Article
- Article
- The Importance of Regulation in Natural Immunity to HIV.Vaccines · 2021Review
- IRF4 is Correlated with the Conversion to a Th17-Like Phenotype in Regulatory T Cells from the Malignant Pleural Effusion.International journal of general medicine · 2021Article
- Coexpression of Helios in Foxp3Disease markers · 2021Review
- Immune Checkpoints in Viral Infections.Viruses · 2020Review
- Downregulation of miR-4772-3p promotes enhanced regulatory T cell capacity in malignant pleural effusion by elevating Helios levels.Chinese medical journal · 2019Article
- Foxp3BMC immunology · 2019Article
- Distinct epigenetic profiles in children with perinatally-acquired HIV on antiretroviral therapy.Scientific reports · 2019Article
- Immunological Changes in Monocyte Subsets and Their Association With Foxp3Frontiers in immunology · 2019Article
- Increased Regulatory T-Cell Activity and Enhanced T-Cell Homeostatic Signaling in Slow Progressing HIV-infected Children.Frontiers in immunology · 2019Article
- Plasmodium vivax Infection Impairs Regulatory T-Cell Suppressive Function During Acute Malaria.The Journal of infectious diseases · 2018Article
- Functional Interrogation of Primary Human T Cells via CRISPR Genetic Editing.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Helios + Regulatory T cell frequencies are correlated with control of viral replication and recovery of absolute CD4 T cells counts in early HIV-1 infection.BMC immunology · 2017Article
- HIV-Infected Children Have Elevated Levels of PD-1+ Memory CD4 T Cells With Low Proliferative Capacity and High Inflammatory Cytokine Effector Functions.The Journal of infectious diseases · 2017Article
- B Cell Requirement for Robust Regulatory T Cell Responses to Friend Retrovirus Infection.mBio · 2017Article
- Modeling aging in HIV infection in nonhuman primates to address an emerging challenge of the post-ART era.Current opinion in virology · 2017Review
- Highly-Exposed HIV-1 seronegative Female Commercial Sex Workers sustain in their genital mucosa increased frequencies of tolerogenic myeloid and regulatory T-cells.Scientific reports · 2017Article
- TIGIT and Helios Are Highly Expressed on CD4The Journal of investigative dermatology · 2017Article
- Decreased Helios Expression in Regulatory T Cells in Acute Coronary Syndrome.Disease markers · 2017Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Regulatory T cells (Tregs) are functionally suppressive CD4 T cells, critical for establishing peripheral tolerance and controlling inflammatory responses. Previous reports of Tregs during chronic HIV disease have conflicting results with higher or lower levels compared with controls. Identifying true Tregs with suppressive activity proves challenging during HIV infection, as traditional Treg markers, CD25 and FOXP3, may transiently upregulate expression as a result of immune activation (IA). Helios is an Ikaros family transcription factor that marks natural Tregs with suppressive activity and does not upregulate expression after activation. Coexpression of FOXP3 and Helios has been suggested as a highly specific marker of "bona fide" Tregs. We evaluated Treg subsets by FOXP3 coexpressed with either CD25 or Helios and their association with HIV disease progression in perinatally infected HIV-positive children. Identifying Tregs by FOXP3 coexpression with Helios rather than CD25 revealed markedly higher Treg frequencies, particularly in HIV+ children. Regardless of antiretroviral therapy, HIV-infected children had a selective expansion of memory FOXP3+Helios+ Tregs. The rise in memory Tregs correlated with declining HIV clinical status, indicated by falling CD4 percentages and CD4:CD8 ratios and increasing HIV plasma viremia and IA. In addition, untreated HIV+ children exhibited an imbalance between the levels of Tregs and activated T cells. Finally, memory Tregs expressed IA markers CD38 and Ki67 and exhaustion marker, PD-1, that tightly correlated with a similar phenotype in memory CD4 T cells. Overall, HIV-infected children had significant disruptions of memory Tregs that associated with advancing HIV disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.