ReviewAnnals of intensive care2016
Hyperoxia toxicity after cardiac arrest: What is the evidence?
Review in Annals of intensive care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Near-infrared spectroscopy after out-of-hospital cardiac arrest.Critical care (London, England) · 2019Trial
- Targeting two different levels of both arterial carbon dioxide and arterial oxygen after cardiac arrest and resuscitation: a randomised pilot trial.Intensive care medicine · 2018Trial
- Association of Pediatric Postcardiac Arrest Ventilation and Oxygenation with Survival Outcomes.Annals of the American Thoracic Society · 2024Observational
- Hyperbaric oxygen therapy in the ATLS/ACLS resuscitative management of acutely ill or severely injured patients with severe anemia: a review.Frontiers in medicine · 2024Review
- Hyperoxemia after reperfusion in cardiac arrest patients: a potential dose-response association with 30-day survival.Critical care (London, England) · 2023Observational
- Perioperative hemodynamic protective assessment of adaptive support ventilation usage in pediatric surgical patients.Acute and critical care · 2022Article
- Cardiac phospholipidome is altered during ischemia and reperfusion in an ex vivo rat model.Biochemistry and biophysics reports · 2021Article
- European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care.Intensive care medicine · 2021Article
- Post-resuscitation shock: recent advances in pathophysiology and treatment.Annals of intensive care · 2020Review
- Biological effects of the oxygen molecule in critically ill patients.Journal of intensive care · 2020Review
- Hyperoxygenation With Cardiopulmonary Resuscitation and Targeted Temperature Management Improves Post-Cardiac Arrest Outcomes in Rats.Journal of the American Heart Association · 2020Article
- Excess cerebral oxygen delivery follows return of spontaneous circulation in near-term asphyxiated lambs.Scientific reports · 2020Article
- Acute Hormonal Responses to High-Intensity Interval Training in Hyperoxia.Journal of human kinetics · 2020Article
- Oxygen administration in patients recovering from cardiac arrest: a narrative review.Journal of intensive care · 2020Review
- The changes in cardiopulmonary resuscitation guidelines: from 2000 to the present.Journal of exercise rehabilitation · 2019Review
- Hyperoxia affects the lung tissue: A porcine histopathological and metabolite study using five hours of apneic oxygenation.Metabolism open · 2019Article
- Hyperoxia in post-cardiac arrest: friend or foe?Journal of thoracic disease · 2018Article
- Harmful effects of early hyperoxaemia in patients admitted to general wards: an observational cohort study in South Korea.BMJ open · 2018Observational
- Oxygenation in post-resuscitation care-how much is too much?Journal of thoracic disease · 2018Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review gives an overview of current knowledge on hyperoxia pathophysiology and examines experimental and human evidence of hyperoxia effects after cardiac arrest. Oxygen plays a pivotal role in critical care management as a lifesaving therapy through the compensation of the imbalance between oxygen requirements and supply. However, growing evidence sustains the hypothesis of reactive oxygen species overproduction-mediated toxicity during hyperoxia, thus exacerbating organ failure by various oxidative cellular injuries. In the cardiac arrest context, evidence of hyperoxia effects on outcome is fairly conflicting. Although prospective data are lacking, retrospective studies and meta-analysis suggest that hyperoxia could be associated with an increased mortality. However, data originate from retrospective, heterogeneous and inconsistent studies presenting various biases that are detailed in this review. Therefore, after an original and detailed analysis of all experimental and clinical studies, we herein provide new ideas and concepts that could participate to improve knowledge on oxygen toxicity and help in developing further prospective controlled randomized trials on this topic. Up to now, the strategy recommended by international guidelines on cardiac arrest (i.e., targeting an oxyhemoglobin saturation of 94-98 %) should be applied in order to avoid deleterious hypoxia and potent hyperoxia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.