ArticlePloS one2016
D-Serine and Glycine Differentially Control Neurotransmission during Visual Cortex Critical Period.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Detection and functional assessment of D-amino acids as potential biomarkers in neurological disorders.Molecular biology reports · 2025Review
- D-Serine's Journey Between Stars and Synapses.Neurochemical research · 2025Review
- Multi-omics insights into the microbiota-gut-brain axis and cognitive improvement post-bariatric surgery.Journal of translational medicine · 2024Article
- d-Serine Inhibits Non-ionotropic NMDA Receptor Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Cross species review of the physiological role of D-serine in translationally relevant behaviors.Amino acids · 2023Review
- Information-Rich, Dual-FunctionJournal of the American Chemical Society · 2023Article
- Search for serum biomarkers in patients with bipolar disorder and major depressive disorder using metabolome analysis.Frontiers in psychiatry · 2023Article
- ILBInternational journal of molecular sciences · 2022Article
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- NMDARs, Coincidence Detectors of Astrocytic and Neuronal Activities.International journal of molecular sciences · 2021Review
- Plasma Metabolomics Profiling of Metabolic Pathways Affected by Major Depressive Disorder.Frontiers in psychiatry · 2021Article
- Postsynaptic Serine Racemase Regulates NMDA Receptor Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- L-serine synthesis via the phosphorylated pathway in humans.Cellular and molecular life sciences : CMLS · 2020Review
- Investigating brain d-serine: Advocacy for good practices.Acta physiologica (Oxford, England) · 2019Review
- Neuronal serine racemase associates with Disrupted-In-Schizophrenia-1 and DISC1 agglomerates: Implications for schizophrenia.Neuroscience letters · 2019Article
- Human Serine Racemase: Key Residues/Active Site Motifs and Their Relation to Enzyme Function.Frontiers in molecular biosciences · 2019Review
- The Role of Serine Racemase in the Pathophysiology of Brain Disorders.Advances in pharmacology (San Diego, Calif.) · 2018Review
- Potential and Challenges for the Clinical Use of d-Serine As a Cognitive Enhancer.Frontiers in psychiatry · 2018Review
- The Gliotransmitter d-Serine Promotes Synapse Maturation and Axonal StabilizationThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
N-methyl-D-aspartate receptors (NMDARs) play a central role in synaptic plasticity. Their activation requires the binding of both glutamate and d-serine or glycine as co-agonist. The prevalence of either co-agonist on NMDA-receptor function differs between brain regions and remains undetermined in the visual cortex (VC) at the critical period of postnatal development. Here, we therefore investigated the regulatory role that d-serine and/or glycine may exert on NMDARs function and on synaptic plasticity in the rat VC layer 5 pyramidal neurons of young rats. Using selective enzymatic depletion of d-serine or glycine, we demonstrate that d-serine and not glycine is the endogenous co-agonist of synaptic NMDARs required for the induction and expression of Long Term Potentiation (LTP) at both excitatory and inhibitory synapses. Glycine on the other hand is not involved in synaptic efficacy per se but regulates excitatory and inhibitory neurotransmission by activating strychnine-sensitive glycine receptors, then producing a shunting inhibition that controls neuronal gain and results in a depression of synaptic inputs at the somatic level after dendritic integration. In conclusion, we describe for the first time that in the VC both D-serine and glycine differentially regulate somatic depolarization through the activation of distinct synaptic and extrasynaptic receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.