ArticleThe Journal of clinical endocrinology and metabolism2016
Fibroblast Growth Factor-23 (FGF-23) Levels Differ Across Populations by Degree of Industrialization.
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Article in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Effects of vitamin D supplementation on FGF23: a randomized-controlled trial.European journal of nutrition · 2019Trial
- Short and long-term effects of kidney donation on mineral and bone metabolism.BMC nephrology · 2024Article
- Raised FGF23 Correlates to Increased Mortality in Critical Illness, Independent of Vitamin D.Biology · 2023Article
- A Comparative Study of Serum Phosphate and Related Parameters in Chronic Kidney Disease between the USA and Japan.American journal of nephrology · 2022Article
- Incidence rate of vitamin D deficiency and FGF23 levels in 12- to 13-year-old adolescents in Japan.Journal of bone and mineral metabolism · 2021Article
- Nutraceutical, Dietary, and Lifestyle Options for Prevention and Treatment of Ventricular Hypertrophy and Heart Failure.International journal of molecular sciences · 2021Review
- High Fibroblast Growth Factor 23 as a Biomarker for Severe Cardiac Impairment in Children with Chronic Kidney Disease: A Single Tertiary Center Study.International journal of nephrology and renovascular disease · 2021Article
- An Overview of FGF-23 as a Novel Candidate Biomarker of Cardiovascular Risk.Frontiers in physiology · 2021Review
- Fibroblast Growth Factor-23 and a Vegetarian Diet.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2020Article
- Fibroblast Growth Factor 23 is Associated with a Frequent Exacerbator Phenotype in COPD: A Cross-Sectional Pilot Study.International journal of molecular sciences · 2019Article
- Dietary factors and fibroblast growth factor-23 levels in young adults with African ancestry.Journal of bone and mineral metabolism · 2017Article
- Novel bone metabolism-associated hormones: the importance of the pre-analytical phase for understanding their physiological roles.Endocrine · 2017Review
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Authors and funding
13 authors at 7 institutions in 6 countries.
Shennin N YuenDepartments of Public Health Sciences (S.N.Y., H.K., A.L., R.H., L.D., R.C., R.D.-A.) and Medicine (H.K.), Division of Nephrology and Hypertension, and Division of Endocrinology (P.C.), Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153; Institute of Social and Preventive Medicine (P.B.), Division of Chronic Disease, Biopole 2, Bureau no. 01-171, 1010 Lausanne, Switzerland; Ministry of Health (P.B.), Victoria, Republic of Seychelles; School of Medical Sciences, Kwame Nkrumah University of Science and Technology (J.P.-R.), Kumasi, Ghana; Tropical Medicine Research Institute (T.F.), University of the West Indies, Solutions for Developing Countries, Mona, Kingston 7, Jamaica; Department of Human Biology (V.L.), Division of Exercise Science and Sports Medicine, Division of Exercise Science and Sports Medicine Department of Human Biology, Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Newlands, 7725 Cape Town, South Africa and Institute of Public Health Sciences (M.W.), Northwestern Medical Center, Chicago, Illinois 60208.
Holly KramerDepartments of Public Health Sciences (S.N.Y., H.K., A.L., R.H., L.D., R.C., R.D.-A.) and Medicine (H.K.), Division of Nephrology and Hypertension, and Division of Endocrinology (P.C.), Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153; Institute of Social and Preventive Medicine (P.B.), Division of Chronic Disease, Biopole 2, Bureau no. 01-171, 1010 Lausanne, Switzerland; Ministry of Health (P.B.), Victoria, Republic of Seychelles; School of Medical Sciences, Kwame Nkrumah University of Science and Technology (J.P.-R.), Kumasi, Ghana; Tropical Medicine Research Institute (T.F.), University of the West Indies, Solutions for Developing Countries, Mona, Kingston 7, Jamaica; Department of Human Biology (V.L.), Division of Exercise Science and Sports Medicine, Division of Exercise Science and Sports Medicine Department of Human Biology, Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Newlands, 7725 Cape Town, South Africa and Institute of Public Health Sciences (M.W.), Northwestern Medical Center, Chicago, Illinois 60208.
Amy LukeDepartments of Public Health Sciences (S.N.Y., H.K., A.L., R.H., L.D., R.C., R.D.-A.) and Medicine (H.K.), Division of Nephrology and Hypertension, and Division of Endocrinology (P.C.), Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153; Institute of Social and Preventive Medicine (P.B.), Division of Chronic Disease, Biopole 2, Bureau no. 01-171, 1010 Lausanne, Switzerland; Ministry of Health (P.B.), Victoria, Republic of Seychelles; School of Medical Sciences, Kwame Nkrumah University of Science and Technology (J.P.-R.), Kumasi, Ghana; Tropical Medicine Research Institute (T.F.), University of the West Indies, Solutions for Developing Countries, Mona, Kingston 7, Jamaica; Department of Human Biology (V.L.), Division of Exercise Science and Sports Medicine, Division of Exercise Science and Sports Medicine Department of Human Biology, Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Newlands, 7725 Cape Town, South Africa and Institute of Public Health Sciences (M.W.), Northwestern Medical Center, Chicago, Illinois 60208.
Pascal BovetDepartments of Public Health Sciences (S.N.Y., H.K., A.L., R.H., L.D., R.C., R.D.-A.) and Medicine (H.K.), Division of Nephrology and Hypertension, and Division of Endocrinology (P.C.), Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153; Institute of Social and Preventive Medicine (P.B.), Division of Chronic Disease, Biopole 2, Bureau no. 01-171, 1010 Lausanne, Switzerland; Ministry of Health (P.B.), Victoria, Republic of Seychelles; School of Medical Sciences, Kwame Nkrumah University of Science and Technology (J.P.-R.), Kumasi, Ghana; Tropical Medicine Research Institute (T.F.), University of the West Indies, Solutions for Developing Countries, Mona, Kingston 7, Jamaica; Department of Human Biology (V.L.), Division of Exercise Science and Sports Medicine, Division of Exercise Science and Sports Medicine Department of Human Biology, Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Newlands, 7725 Cape Town, South Africa and Institute of Public Health Sciences (M.W.), Northwestern Medical Center, Chicago, Illinois 60208.
Jacob Plange-RhuleDepartments of Public Health Sciences (S.N.Y., H.K., A.L., R.H., L.D., R.C., R.D.-A.) and Medicine (H.K.), Division of Nephrology and Hypertension, and Division of Endocrinology (P.C.), Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153; Institute of Social and Preventive Medicine (P.B.), Division of Chronic Disease, Biopole 2, Bureau no. 01-171, 1010 Lausanne, Switzerland; Ministry of Health (P.B.), Victoria, Republic of Seychelles; School of Medical Sciences, Kwame Nkrumah University of Science and Technology (J.P.-R.), Kumasi, Ghana; Tropical Medicine Research Institute (T.F.), University of the West Indies, Solutions for Developing Countries, Mona, Kingston 7, Jamaica; Department of Human Biology (V.L.), Division of Exercise Science and Sports Medicine, Division of Exercise Science and Sports Medicine Department of Human Biology, Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Newlands, 7725 Cape Town, South Africa and Institute of Public Health Sciences (M.W.), Northwestern Medical Center, Chicago, Illinois 60208.
Terrence ForresterDepartments of Public Health Sciences (S.N.Y., H.K., A.L., R.H., L.D., R.C., R.D.-A.) and Medicine (H.K.), Division of Nephrology and Hypertension, and Division of Endocrinology (P.C.), Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153; Institute of Social and Preventive Medicine (P.B.), Division of Chronic Disease, Biopole 2, Bureau no. 01-171, 1010 Lausanne, Switzerland; Ministry of Health (P.B.), Victoria, Republic of Seychelles; School of Medical Sciences, Kwame Nkrumah University of Science and Technology (J.P.-R.), Kumasi, Ghana; Tropical Medicine Research Institute (T.F.), University of the West Indies, Solutions for Developing Countries, Mona, Kingston 7, Jamaica; Department of Human Biology (V.L.), Division of Exercise Science and Sports Medicine, Division of Exercise Science and Sports Medicine Department of Human Biology, Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Newlands, 7725 Cape Town, South Africa and Institute of Public Health Sciences (M.W.), Northwestern Medical Center, Chicago, Illinois 60208.
Vicki LambertDepartments of Public Health Sciences (S.N.Y., H.K., A.L., R.H., L.D., R.C., R.D.-A.) and Medicine (H.K.), Division of Nephrology and Hypertension, and Division of Endocrinology (P.C.), Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153; Institute of Social and Preventive Medicine (P.B.), Division of Chronic Disease, Biopole 2, Bureau no. 01-171, 1010 Lausanne, Switzerland; Ministry of Health (P.B.), Victoria, Republic of Seychelles; School of Medical Sciences, Kwame Nkrumah University of Science and Technology (J.P.-R.), Kumasi, Ghana; Tropical Medicine Research Institute (T.F.), University of the West Indies, Solutions for Developing Countries, Mona, Kingston 7, Jamaica; Department of Human Biology (V.L.), Division of Exercise Science and Sports Medicine, Division of Exercise Science and Sports Medicine Department of Human Biology, Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Newlands, 7725 Cape Town, South Africa and Institute of Public Health Sciences (M.W.), Northwestern Medical Center, Chicago, Illinois 60208.
Myles WolfDepartments of Public Health Sciences (S.N.Y., H.K., A.L., R.H., L.D., R.C., R.D.-A.) and Medicine (H.K.), Division of Nephrology and Hypertension, and Division of Endocrinology (P.C.), Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153; Institute of Social and Preventive Medicine (P.B.), Division of Chronic Disease, Biopole 2, Bureau no. 01-171, 1010 Lausanne, Switzerland; Ministry of Health (P.B.), Victoria, Republic of Seychelles; School of Medical Sciences, Kwame Nkrumah University of Science and Technology (J.P.-R.), Kumasi, Ghana; Tropical Medicine Research Institute (T.F.), University of the West Indies, Solutions for Developing Countries, Mona, Kingston 7, Jamaica; Department of Human Biology (V.L.), Division of Exercise Science and Sports Medicine, Division of Exercise Science and Sports Medicine Department of Human Biology, Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Newlands, 7725 Cape Town, South Africa and Institute of Public Health Sciences (M.W.), Northwestern Medical Center, Chicago, Illinois 60208.
Pauline CamachoDepartments of Public Health Sciences (S.N.Y., H.K., A.L., R.H., L.D., R.C., R.D.-A.) and Medicine (H.K.), Division of Nephrology and Hypertension, and Division of Endocrinology (P.C.), Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153; Institute of Social and Preventive Medicine (P.B.), Division of Chronic Disease, Biopole 2, Bureau no. 01-171, 1010 Lausanne, Switzerland; Ministry of Health (P.B.), Victoria, Republic of Seychelles; School of Medical Sciences, Kwame Nkrumah University of Science and Technology (J.P.-R.), Kumasi, Ghana; Tropical Medicine Research Institute (T.F.), University of the West Indies, Solutions for Developing Countries, Mona, Kingston 7, Jamaica; Department of Human Biology (V.L.), Division of Exercise Science and Sports Medicine, Division of Exercise Science and Sports Medicine Department of Human Biology, Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Newlands, 7725 Cape Town, South Africa and Institute of Public Health Sciences (M.W.), Northwestern Medical Center, Chicago, Illinois 60208.
Regina HardersDepartments of Public Health Sciences (S.N.Y., H.K., A.L., R.H., L.D., R.C., R.D.-A.) and Medicine (H.K.), Division of Nephrology and Hypertension, and Division of Endocrinology (P.C.), Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153; Institute of Social and Preventive Medicine (P.B.), Division of Chronic Disease, Biopole 2, Bureau no. 01-171, 1010 Lausanne, Switzerland; Ministry of Health (P.B.), Victoria, Republic of Seychelles; School of Medical Sciences, Kwame Nkrumah University of Science and Technology (J.P.-R.), Kumasi, Ghana; Tropical Medicine Research Institute (T.F.), University of the West Indies, Solutions for Developing Countries, Mona, Kingston 7, Jamaica; Department of Human Biology (V.L.), Division of Exercise Science and Sports Medicine, Division of Exercise Science and Sports Medicine Department of Human Biology, Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Newlands, 7725 Cape Town, South Africa and Institute of Public Health Sciences (M.W.), Northwestern Medical Center, Chicago, Illinois 60208.
Lara DugasDepartments of Public Health Sciences (S.N.Y., H.K., A.L., R.H., L.D., R.C., R.D.-A.) and Medicine (H.K.), Division of Nephrology and Hypertension, and Division of Endocrinology (P.C.), Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153; Institute of Social and Preventive Medicine (P.B.), Division of Chronic Disease, Biopole 2, Bureau no. 01-171, 1010 Lausanne, Switzerland; Ministry of Health (P.B.), Victoria, Republic of Seychelles; School of Medical Sciences, Kwame Nkrumah University of Science and Technology (J.P.-R.), Kumasi, Ghana; Tropical Medicine Research Institute (T.F.), University of the West Indies, Solutions for Developing Countries, Mona, Kingston 7, Jamaica; Department of Human Biology (V.L.), Division of Exercise Science and Sports Medicine, Division of Exercise Science and Sports Medicine Department of Human Biology, Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Newlands, 7725 Cape Town, South Africa and Institute of Public Health Sciences (M.W.), Northwestern Medical Center, Chicago, Illinois 60208.
Richard CooperDepartments of Public Health Sciences (S.N.Y., H.K., A.L., R.H., L.D., R.C., R.D.-A.) and Medicine (H.K.), Division of Nephrology and Hypertension, and Division of Endocrinology (P.C.), Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153; Institute of Social and Preventive Medicine (P.B.), Division of Chronic Disease, Biopole 2, Bureau no. 01-171, 1010 Lausanne, Switzerland; Ministry of Health (P.B.), Victoria, Republic of Seychelles; School of Medical Sciences, Kwame Nkrumah University of Science and Technology (J.P.-R.), Kumasi, Ghana; Tropical Medicine Research Institute (T.F.), University of the West Indies, Solutions for Developing Countries, Mona, Kingston 7, Jamaica; Department of Human Biology (V.L.), Division of Exercise Science and Sports Medicine, Division of Exercise Science and Sports Medicine Department of Human Biology, Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Newlands, 7725 Cape Town, South Africa and Institute of Public Health Sciences (M.W.), Northwestern Medical Center, Chicago, Illinois 60208.
Ramon Durazo-ArvizuDepartments of Public Health Sciences (S.N.Y., H.K., A.L., R.H., L.D., R.C., R.D.-A.) and Medicine (H.K.), Division of Nephrology and Hypertension, and Division of Endocrinology (P.C.), Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153; Institute of Social and Preventive Medicine (P.B.), Division of Chronic Disease, Biopole 2, Bureau no. 01-171, 1010 Lausanne, Switzerland; Ministry of Health (P.B.), Victoria, Republic of Seychelles; School of Medical Sciences, Kwame Nkrumah University of Science and Technology (J.P.-R.), Kumasi, Ghana; Tropical Medicine Research Institute (T.F.), University of the West Indies, Solutions for Developing Countries, Mona, Kingston 7, Jamaica; Department of Human Biology (V.L.), Division of Exercise Science and Sports Medicine, Division of Exercise Science and Sports Medicine Department of Human Biology, Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Newlands, 7725 Cape Town, South Africa and Institute of Public Health Sciences (M.W.), Northwestern Medical Center, Chicago, Illinois 60208.
Illinois Department of Public Health · USKwame Nkrumah University of Science and Technology · GHLoyola University Chicago · USMinistry of Health · SCNorthwestern Medicine · USUniversity of Cape Town · ZAUniversity of the West Indies System · JM
Funding
Determinants and Consequences of Low Vitamin D in Populations of African DescentR01DK090360 · NIDDK · LOYOLA UNIVERSITY CHICAGO · PI DURAZO-ARVIZU, RAMON ANGEL · 2011 to 2015
$3.0MModeling the epidemiologic transition: Energy expenditure, obesity and diabetesR01DK080763 · NIDDK · LOYOLA UNIVERSITY CHICAGO · PI LUKE, AMY H · 2009 to 2012
$2.4MNIDDK NIH HHS R01 DK080763NIDDK NIH HHS R01 DK090360
Abstract
contextCompensatory increases in fibroblast growth factor 23 (FGF23) with increasing phosphate intake may adversely impact health. However, population and clinical studies examining the link between phosphate intake and FGF23 levels have focused mainly on populations living in highly industrialized societies in which phosphate exposure may be homogenous.
objectiveThe objective of the study was to contrast dietary phosphate intake, urinary measures of phosphate excretion, and FGF23 levels across populations that differ by the level of industrialization.
designThis was a cross-sectional analysis of three populations.
settingThe study was conducted in Maywood, Illinois; Mahé Island, Seychelles; and Kumasi, Ghana.
participantsAdults with African ancestry aged 25-45 years participated in the study. MAIN OUTCOME: FGF23 levels were measured.
resultsThe mean age was 35.1 (6.3) years and 47.9% were male. Mean phosphate intake and fractional excretion of phosphate were significantly higher in the United States vs Ghana, whereas no significant difference in phosphate intake or fractional excretion of phosphate was noted between the United States and Seychelles for men or women. Overall, median FGF23 values were 57.41 RU/mL (interquartile range [IQR] 43.42, 75.09) in the United States, 42.49 RU/mL (IQR 33.06, 55.39) in Seychelles, and 33.32 RU/mL (IQR 24.83, 47.36) in Ghana. In the pooled sample, FGF23 levels were significantly and positively correlated with dietary phosphate intake (r = 0.11; P < .001) and the fractional excretion of phosphate (r = 0.13; P < .001) but not with plasma phosphate levels (r = -0.001; P = .8). Dietary phosphate intake was significantly and positively associated with the fractional excretion of phosphate (r = 0.23; P < .001).
conclusionThe distribution of FGF23 levels in a given population may be influenced by the level of industrialization, likely due to differences in access to foods preserved with phosphate additives.
Indexed as
Industrial DevelopmentAdultBiomarkersCross-Sectional StudiesDietFemaleFibroblast Growth Factor-23Fibroblast Growth FactorsHumansMaleMiddle AgedPhosphatesBiomarkersFGF23 protein, humanFibroblast Growth Factor-23Fibroblast Growth FactorsPhosphates
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