ArticleeLife2016
Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
97 citing papers in PubMed, 2 syntheses or guidelines pooled it, 187 citations in OpenAlex.
- Fixed-dose ivermectin for Mass Drug Administration: Is it time to leave the dose pole behind? Insights from an Individual Participant Data Meta-Analysis.PLoS neglected tropical diseases · 2025Pooled it
- Factors associated with human visceral leishmaniasis cases during urban epidemics in Brazil: a systematic review.Parasitology · 2021Pooled it
- Multi-drug tolerance in Leishmania persister-like cells.Communications biology · 2026Article
- Extensive heterozygosity and genetic exchange among natural populations ofProceedings of the National Academy of Sciences of the United States of America · 2026Article
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- Whole genome sequencing reveals genomic diversity and evidence of hybridization in MoroccanFrontiers in cellular and infection microbiology · 2026Article
- Precision Without Selection: A Marker-Free CRISPR/Cas9-Based Protocol for Multiplexed Genome Editing in Trypanosomatids.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Epidemiological dynamics ofMicrobial genomics · 2025Article
- Unraveling the Genome Diversity ofLife (Basel, Switzerland) · 2025Review
- Interventions for Neglected Diseases Caused by Kinetoplastid Parasites: A One Health Approach to Drug Discovery, Development, and Deployment.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Can cutaneous leishmaniasis provoke a resurgence of kala-azar in the Indian subcontinent?BMC infectious diseases · 2025Article
- Genome analyses of amphotericin B-susceptible and -resistant strains ofCurrent research in parasitology & vector-borne diseases · 2025Article
- Genetic Diversity and Chromosomal Variations in the IranianAdvanced biomedical research · 2025Article
- Understanding the genetic complexity of Leishmania infantum in the Americas: a focus on 3'NT/NU gene deletion.Memorias do Instituto Oswaldo Cruz · 2025Review
- India should invest in the expansion of genomic epidemiology for vector-borne diseases filariasis, malaria and visceral leishmaniasis that are targeted for elimination.IJID regions · 2024Review
- Evolutionary genomics of Leishmania braziliensis across the neotropical realm.Communications biology · 2024Article
- Article
- Investigation of parasite genetic variation and systemic immune responses in patients presenting with different clinical presentations of cutaneous leishmaniasis caused by Leishmania aethiopica.Infectious diseases of poverty · 2024Article
- Source Tracing of Leishmania donovani in Emerging Foci of Visceral Leishmaniasis, Western Nepal.Emerging infectious diseases · 2024Article
- Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
33 authors at 13 institutions in 8 countries.
Funding
Abstract
Leishmania donovani causes visceral leishmaniasis (VL), the second most deadly vector-borne parasitic disease. A recent epidemic in the Indian subcontinent (ISC) caused up to 80% of global VL and over 30,000 deaths per year. Resistance against antimonial drugs has probably been a contributing factor in the persistence of this epidemic. Here we use whole genome sequences from 204 clinical isolates to track the evolution and epidemiology of L. donovani from the ISC. We identify independent radiations that have emerged since a bottleneck coincident with 1960s DDT spraying campaigns. A genetically distinct population frequently resistant to antimonials has a two base-pair insertion in the aquaglyceroporin gene LdAQP1 that prevents the transport of trivalent antimonials. We find evidence of genetic exchange between ISC populations, and show that the mutation in LdAQP1 has spread by recombination. Our results reveal the complexity of L. donovani evolution in the ISC in response to drug treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.