ArticlePediatric radiology2016
Evaluation of diagnostic performance of whole-body simultaneous PET/MRI in pediatric lymphoma.
Article in Pediatric radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Advances in FDG PET imaging for staging and prognostic assessment in pediatric lymphoma: a systematic review.Pediatric radiology · 2026Pooled it
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- Up-to-Date Imaging and Diagnostic Techniques for Prostate Cancer: A Literature Review.Diagnostics (Basel, Switzerland) · 2023Review
- Imaging Inflammation in Atherosclerosis with CXCR4-Directed [Life (Basel, Switzerland) · 2022Article
- PET/MRI in Pediatric Neuroimaging: Primer for Clinical Practice.AJNR. American journal of neuroradiology · 2022Review
- Prognostic Value of Hybrid PET/MR Imaging in Patients with Differentiated Thyroid Cancer.Cancers · 2022Article
- Clinical Perspectives forMetabolites · 2022Review
- One-stop local and whole-body staging of children with cancer.Pediatric radiology · 2022Review
- Magnetic resonance imaging of the pediatric mediastinum: updates, tips and tricks.Pediatric radiology · 2022Review
- Current progress and future trends in imaging of musculoskeletal bone tumours.Journal of clinical orthopaedics and trauma · 2021Article
- Current Role of Functional Imaging in the Management of Lymphoma.Current oncology reports · 2021Review
- Article
- PET/MRI Improves Management of Children with Cancer.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021Review
- Article
- Hybrid imaging of the abdomen and pelvis.Der Radiologe · 2020Review
- [Hybrid imaging of the abdomen and pelvis. German version].Der Radiologe · 2020Review
- Clinical pediatric positron emission tomography/magnetic resonance program: a guide to successful implementation.Pediatric radiology · 2020Review
- Importance of whole-body imaging with complete coverage of hands and feet in alveolar rhabdomyosarcoma staging.Pediatric radiology · 2018Article
- How to Provide Gadolinium-Free PET/MR Cancer Staging of Children and Young Adults in Less than 1 h: the Stanford Approach.Molecular imaging and biology · 2018Article
- PET/MRI: Where might it replace PET/CT?Journal of magnetic resonance imaging : JMRI · 2017Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWhole-body (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is the standard of care for lymphoma. Simultaneous PET/MRI (magnetic resonance imaging) is a promising new modality that combines the metabolic information of PET with superior soft-tissue resolution and functional imaging capabilities of MRI while decreasing radiation dose. There is limited information on the clinical performance of PET/MRI in the pediatric setting.
objectiveThis study evaluated the feasibility, dosimetry, and qualitative and quantitative diagnostic performance of simultaneous whole-body FDG-PET/MRI in children with lymphoma compared to PET/CT. MATERIALS AND
methodsChildren with lymphoma undergoing standard of care FDG-PET/CT were prospectively recruited for PET/MRI performed immediately after the PET/CT. Images were evaluated for quality, lesion detection and anatomical localization of FDG uptake. Maximum and mean standardized uptake values (SUVmax/mean) of normal organs and SUVmax of the most FDG-avid lesions were measured for PET/MRI and PET/CT. Estimation of radiation exposure was calculated using specific age-related factors.
resultsNine PET/MRI scans were performed in eight patients (mean age: 15.3 years). The mean time interval between PET/CT and PET/MRI was 51 ± 10 min. Both the PET/CT and PET/MRI exams had good image quality and alignment with complete (9/9) concordance in response assessment. The SUVs from PET/MRI and PET/CT were highly correlated for normal organs (SUVmean r(2): 0.88, P<0.0001) and very highly for FDG-avid lesions (SUVmax r(2): 0.94, P=0.0002). PET/MRI demonstrated an average percent radiation exposure reduction of 39% ± 13% compared with PET/CT.
conclusionSimultaneous whole-body PET/MRI is clinically feasible in pediatric lymphoma. PET/MRI performance is comparable to PET/CT for lesion detection and SUV measurements. Replacement of PET/CT with PET/MRI can significantly decrease radiation dose from diagnostic imaging in children.
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