ArticlePediatric research2016
Clinical associations with immature breathing in preterm infants: part 2-periodic breathing.
Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 62 citations in OpenAlex.
- Cardiorespiratory measures shortly after extubation and extubation outcomes in extremely preterm infants.Pediatric research · 2023Trial
- Short apneas and periodic breathing in preterm infants in the neonatal intensive care unit-Effects of sleep position, sleep state, and age.Journal of sleep research · 2025Observational
- Sleep state-dependent development of resting-state functional connectivity during the preterm period.Sleep · 2024Article
- Apnea, Intermittent Hypoxemia, and Bradycardia Events Predict Late-Onset Sepsis in Infants Born Extremely Preterm.The Journal of pediatrics · 2024Observational
- SubSol-HIe is an AMPK-dependent hypoxia-responsive subnucleus of the nucleus tractus solitarius that coordinates the hypoxic ventilatory response and protects against apnoea in mice.Pflugers Archiv : European journal of physiology · 2024Article
- Heart Rate and Pulse Oximetry Dynamics in the First Week after Birth in Neonatal Intensive Care Unit Patients and the Risk of Cerebral Palsy.American journal of perinatology · 2024Article
- Maturation of cardioventilatory physiological trajectories in extremely preterm infants.Pediatric research · 2024Article
- Evaluation of a contactless neonatal physiological monitor in Nairobi, Kenya.Archives of disease in childhood · 2022Observational
- Contactless radar-based breathing monitoring of premature infants in the neonatal intensive care unit.Scientific reports · 2022Article
- Multichannel esophageal signals to monitor respiratory rate in preterm infants.Pediatric research · 2022Observational
- Apnea of prematurity and sudden infant death syndrome.Handbook of clinical neurology · 2022Review
- Precision caffeine therapy for apnea of prematurity and circadian rhythms: New possibilities open up.Frontiers in pharmacology · 2022Review
- Vital signs as physiomarkers of neonatal sepsis.Pediatric research · 2022Review
- Immature control of breathing and apnea of prematurity: the known and unknown.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Diaphragmatic activity and neural breathing variability during a 5-min endotracheal continuous positive airway pressure trial in extremely preterm infants.Pediatric research · 2021Article
- Towards Continuous Camera-Based Respiration Monitoring in Infants.Sensors (Basel, Switzerland) · 2021Article
- Multi-camera infrared thermography for infant respiration monitoring.Biomedical optics express · 2020Article
- Continuous vital sign analysis for predicting and preventing neonatal diseases in the twenty-first century: big data to the forefront.Pediatric research · 2020Review
- Postmenstrual age at discharge in premature infants with and without ventilatory pattern instability.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Sleep-related risk and worrying behaviours: a retrospective review of a tertiary centre's experience.European journal of pediatrics · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPeriodic breathing (PB) is a normal immature breathing pattern in neonates that, if extreme, may be associated with pathologic conditions.
methodsWe used our automated PB detection system to analyze all bedside monitor chest impedance data on all infants <35 wk' gestation in the University of Virginia Neonatal Intensive Care Unit from 2009-2014 (n = 1,211). Percent time spent in PB was calculated hourly (>50 infant-years' data). Extreme PB was identified as a 12-h period with PB >6 SDs above the mean for gestational age (GA) and postmenstrual age and >10% time in PB.
resultsPB increased with GA, with the highest amount in infants 30-33 wk' GA at about 2 wk' chronologic age. Extreme PB was identified in 76 infants and in 45% was temporally associated with clinical events including infection or necrotizing enterocolitis (NEC), immunizations, or caffeine discontinuation. In 8 out of 28 cases of septicemia and 10 out of 21 cases of NEC, there was a >2-fold increase in %PB over baseline on the day prior to diagnosis.
conclusionInfants <35 wk GA spend, on average, <6% of the time in PB. An acute increase in PB may reflect illness or physiological stressors or may occur without any apparent clinical event.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.