ArticleBritish journal of cancer2016
Effect of leaving chronic oral foci untreated on infectious complications during intensive chemotherapy.
Article in British journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- A systematic review of dental disease management in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Pooled it
- Antibiotic prophylaxis is not indicated prior to dental procedures for prevention of periprosthetic joint infections.Acta orthopaedica · 2017Guideline
- Association between oral ulcerative lesions, oral infections, and fever during the pre-engraftment phase after hematopoietic cell transplantation: results from the Orastem study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Observational
- The Importance of Dental Treatment in Patients Before Radiotherapy, Chemotherapy, and Cardiac Surgeries: A Narrative Review.Journal of clinical medicine · 2025Review
- Oral foci of infection and their relationship with hospital stay after haematopoietic cell transplantation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Do oral conditions influence the incidence of bloodstream infection after hematopoietic stem cell transplantation? A retrospective study in Japan.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Dental evaluation and clearance prior to allogeneic hematopoietic cell transplantation.Oral diseases · 2024Article
- Pre-Chemotherapy Dental Screening: Is There Additional Diagnostic Value for a Panoramic Radiograph?Dentistry journal · 2023Article
- Oral health in patients scheduled for hematopoietic stem cell transplantation in the Orastem study.PloS one · 2023Observational
- FDG-PET/CT for oral focus assessment in head and neck cancer patients.Clinical oral investigations · 2022Article
- The Potential Contribution of Dental Foci and Oral Mucositis to Febrile Neutropenia in Patients Treated With Myelosuppressive Chemotherapy for Solid Tumors and Lymphoma.Frontiers in oral health · 2022Article
- Dental status and risk of odontogenic complication in patients undergoing hematopoietic stem cell transplant.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Should oral foci of infection be removed before the onset of radiotherapy or chemotherapy?Oral diseases · 2021Review
- Deciphering novel chemotherapy and its impact on dentistry.British dental journal · 2020Article
- Apical periodontitis as potential source of infection in patients with lymphoma treated with chemotherapy.Clinical oral investigations · 2020Article
- The impact of the oral cavity in febrile neutropenia and infectious complications in patients treated with myelosuppressive chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Review
- Dissociations of oral foci of infections with infectious complications and survival after haematopoietic stem cell transplantation.PloS one · 2019Article
- Oral health of adult patients undergoing hematopoietic cell transplantation. Pre-transplant assessment and care.Annals of hematology · 2017Review
- Assessment of oral health condition in recipients of allogeneic hematopoietic cell transplantation.Hematology, transfusion and cell therapyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeukaemic patients receiving intensive chemotherapy and patients undergoing autologous stem-cell transplantation (ASCT) are routinely screened for oral foci of infection to reduce infectious complications that could occur during therapy. In this prospective study we assessed the effect of leaving chronic oral foci of infection untreated on the development of infectious complications in intensively treated haematological patients.
methodsWe included and prospectively evaluated all intensively treated leukaemic patients and patients undergoing ASCT who were referred to our medical centre between September 2012 and May 2014, and who matched the inclusion/exclusion criteria. Acute oral foci of infection were removed before chemotherapy or ASCT, whereas chronic oral foci were left untreated.
resultsIn total 28 leukaemic and 35 ASCT patients were included. Acute oral foci of infection were found in 2 leukaemic (7%) and 2 ASCT patients (6%), and chronic oral foci of infection in 24 leukaemic (86%) and 22 ASCT patients (63%). Positive blood cultures with microorganisms potentially originating from the oral cavity occurred in 7 patients during treatment, but were uneventful on development of infectious complications.
conclusionsOur prospective study supports the hypothesis that chronic oral foci of infection can be left untreated as this does not increase infectious complications during intensive chemotherapy.
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