Evidence map›Paper›PMID 27002515›Full record

ReviewCurrent allergy and asthma reports2016

Pollen Allergens for Molecular Diagnosis.

Isabel Pablos, Sabrina Wildner, Claudia Asam, Michael Wallner, Gabriele Gadermaier

Registry-linked trialAbstract readReview
In one paragraph

Review in Current allergy and asthma reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04801823 (Can Early Introduction of Tree Nuts Prevent Tree Nut Allergy in Infants at High Risk of Tree Nut Allergy), which is not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04801823 phase3completednot on this mapstarted 2021, after this paper: background citation

Can Early Introduction of Tree Nuts Prevent Tree Nut Allergy in Infants at High Risk of Tree Nut Allergy: The TreEat Study: a Randomised, Open-label Controlled Trial

TypeinterventionalSponsorMurdoch Childrens Research InstituteRan2021 to 2025Enrolled212ConditionsFood Allergy in Infants, Nut AllergyArmsHome introduction, Multi Nut oral food challenge
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Efficacy and safety ofThe Journal of international medical research · 2026
    Observational
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Prevalence of allergic sensitization toAsia Pacific allergy · 2024
    Article
  12. Article
  13. Dissecting Airborne Allergens.Journal of clinical medicine · 2023
    Review
  14. Perspectives of Proteomics in Respiratory Allergic Diseases.International journal of molecular sciences · 2023
    Review
  15. Review
  16. Review
  17. Article
  18. An allergenic plant calmodulin fromFrontiers in immunology · 2022
    Article
  19. How Do Pollen Allergens Sensitize?Frontiers in molecular biosciences · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Isabel PablosDepartment of Molecular Biology, University of Salzburg, Hellbrunner Straße 34, 5020, Salzburg, Austria.
Sabrina WildnerChristian Doppler Laboratory for Biosimilar Characterization, University of Salzburg, Hellbrunner Straße 34, 5020, Salzburg, Austria.
Claudia AsamDepartment of Molecular Biology, University of Salzburg, Hellbrunner Straße 34, 5020, Salzburg, Austria.
Michael WallnerDepartment of Molecular Biology, University of Salzburg, Hellbrunner Straße 34, 5020, Salzburg, Austria.
Gabriele GadermaierDepartment of Molecular Biology, University of Salzburg, Hellbrunner Straße 34, 5020, Salzburg, Austria. Gabriele.Gadermaier@sbg.ac.at.

Funding

Austrian Science Fund FWF L 688Austrian Science Fund FWF P 27589
6 · The paper itself

Abstract

Pollen allergens are one of the main causes of type I allergies affecting up to 30% of the population in industrialized countries. Climatic changes affect the duration and intensity of pollen seasons and may together with pollution contribute to increased incidences of respiratory allergy and asthma. Allergenic grasses, trees, and weeds often present similar habitats and flowering periods compromising clinical anamnesis. Molecule-based approaches enable distinction between genuine sensitization and clinically mostly irrelevant IgE cross-reactivity due to, e. g., panallergens or carbohydrate determinants. In addition, sensitivity as well as specificity can be improved and lead to identification of the primary sensitizing source which is particularly beneficial regarding polysensitized patients. This review gives an overview on relevant pollen allergens and their usefulness in daily practice. Appropriate allergy diagnosis is directly influencing decisions for therapeutic interventions, and thus, reliable biomarkers are pivotal when considering allergen immunotherapy in the context of precision medicine.

Indexed as

Molecular Diagnostic TechniquesAllergensDesensitization, ImmunologicHumansPollenRhinitis, AllergicAllergensGrass pollen allergensMolecule-based diagnosisPollen allergensTree pollen allergensWeed pollen allergens

Identifiers

PMID27002515
PMCPMC4803804

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.