ArticleInvestigative ophthalmology & visual science2016
Elevated Fundus Autofluorescence in Monkeys Deficient in Lutein, Zeaxanthin, and Omega-3 Fatty Acids.
Article in Investigative ophthalmology & visual science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Wide-field OCT angiography for non-human primate retinal imaging.Biomedical optics express · 2024Article
- Development of a translatable gene augmentation therapy for CNGB1-retinitis pigmentosa.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Article
- CRISPR/Cas9 editing of the MYO7A gene in rhesus macaque embryos to generate a primate model of Usher syndrome type 1B.Scientific reports · 2022Article
- Advanced Retinal Imaging and Ocular Parameters of the Rhesus Macaque Eye.Translational vision science & technology · 2021Article
- Quantitative Fundus Autofluorescence in Rhesus Macaques in Aging and Age-Related Drusen.Investigative ophthalmology & visual science · 2020Article
- A low glycemic diet protects disease-prone Nrf2-deficient mice against age-related macular degeneration.Free radical biology & medicine · 2020Article
- Long-term Evolution and Remodeling of Soft Drusen in Rhesus Macaques.Investigative ophthalmology & visual science · 2020Article
- Polarization perception in humans: on the origin of and relationship between Maxwell's spot and Haidinger's brushes.Scientific reports · 2020Article
- Bardet-Biedl Syndrome in rhesus macaques: A nonhuman primate model of retinitis pigmentosa.Experimental eye research · 2019Article
- Discovery of a CLN7 model of Batten disease in non-human primates.Neurobiology of disease · 2018Article
- The Ultrastructure, Spatial Distribution, and Osmium Tetroxide Binding of Lipofuscin and Melanosomes in Aging Monkey Retinal Epithelium.Current eye research · 2018Article
- Allogeneic iPSC-Derived RPE Cell Graft Failure Following Transplantation Into the Subretinal Space in Nonhuman Primates.Investigative ophthalmology & visual science · 2018Article
- In Vivo Multimodal Imaging of Drusenoid Lesions in Rhesus Macaques.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purposeWe quantified fundus autofluorescence (FAF) in the nonhuman primate retina as a function of age and diets lacking lutein and zeaxanthin (L/Z) and omega-3 fatty acids.
methodsQuantitative FAF was measured in a cross-sectional study of rhesus macaques fed a standard diet across the lifespan, and in aged rhesus macaques fed lifelong diets lacking L/Z and providing either adequate or deficient levels of omega-3 fatty acids. Macular FAF images were segmented into multiple regions of interest, and mean gray values for each region were calculated using ImageJ. The resulting FAF values were compared across ages within the standard diet animals, and among diet groups and regions.
resultsFundus autofluorescence increased with age in the standard diet animals, and was highest in the perifovea. Monkeys fed L/Z-free diets with either adequate or deficient omega-3 fatty acids had significantly higher FAF overall than age-matched standard diet monkeys. Examined by region, those with adequate omega-3 fatty acids had higher FAF in the fovea and superior regions, while monkeys fed the diet lacking L/Z and omega-3 fatty acids had higher FAF in all regions.
conclusionsDiets devoid of L/Z resulted in increased retinal autofluorescence, with the highest values in animals also lacking omega-3 fatty acids. The increase was equivalent to a 12- to 20-year acceleration in lipofuscin accumulation compared to animals fed a standard diet. Together these data add support for the role of these nutrients as important factors in lipofuscin accumulation, retinal aging, and progression of macular disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.