ArticleThe Plant cell2016
S-type Anion Channels SLAC1 and SLAH3 Function as Essential Negative Regulators of Inward K+ Channels and Stomatal Opening in Arabidopsis.
Article in The Plant cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 74 citations in OpenAlex.
- COJournal of integrative plant biology · 2026Article
- Local peptide signalling induces stomatal closure under drought stress.Nature communications · 2025Article
- Transcriptional signatures associated with waterlogging stress responses and aerenchyma formation in barley root tissue.Annals of botany · 2025Article
- Roles of ROS and NO in Plant Responses to Individual and Combined Salt Stress and Waterlogging.Antioxidants (Basel, Switzerland) · 2025Review
- ALMT12 interacts with and inhibits SLAC1 to modulate stomatal movements and enhance plant biomass.Plant physiology · 2025Article
- Quantitative trait locus mapping for salt and drought tolerance traits in wheat (Triticum aestivum L.).BMC plant biology · 2025Article
- The transcription factor OsNAC25 regulates potassium homeostasis in rice.Plant biotechnology journal · 2025Article
- Chloride transport and homeostasis in plants.Quantitative plant biology · 2025Review
- Molecular Regulation of Photosynthetic Carbon Assimilation in Oat Leaves Under Drought Stress.Plants (Basel, Switzerland) · 2024Article
- Stomatal CO2 responses at sub- and above-ambient CO2 levels employ different pathways in Arabidopsis.Plant physiology · 2024Article
- Mechanistic insights into phosphoactivation of SLAC1 in guard cell signaling.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- OPEN STOMATA 1 phosphorylates CYCLIC NUCLEOTIDE-GATED CHANNELs to trigger Ca2+ signaling for abscisic acid-induced stomatal closure in Arabidopsis.The Plant cell · 2024Article
- Role of methylglyoxal and glyoxalase in the regulation of plant response to heavy metal stress.Plant cell reports · 2024Review
- The anion channel SLAH3 interacts with potassium channels to regulate nitrogen-potassium homeostasis and the membrane potential in Arabidopsis.The Plant cell · 2023Article
- Multiple cyclic nucleotide-gated channels function as ABA-activated Ca2+ channels required for ABA-induced stomatal closure in Arabidopsis.The Plant cell · 2023Article
- Syntaxin of plants71 plays essential roles in plant development and stress response via regulating pH homeostasis.Frontiers in plant science · 2023Article
- Drought priming mechanisms in wheat elucidated byFrontiers in plant science · 2023Article
- Roles of Glutamate Receptor-Like Channels (GLRs) in Plant Growth and Response to Environmental Stimuli.Plants (Basel, Switzerland) · 2022Review
- Constitutive activation of a nuclear-localized calcium channel complex inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genome-wide identification and in silico analysis of NPF, NRT2, CLC and SLAC1/SLAH nitrate transporters in hexaploid wheat (Triticum aestivum).Scientific reports · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drought stress induces stomatal closure and inhibits stomatal opening simultaneously. However, the underlying molecular mechanism is still largely unknown. Here we show that S-type anion channels SLAC1 and SLAH3 mainly inhibit inward K+ (K+in) channel KAT1 by protein-protein interaction, and consequently prevent stomatal opening in Arabidopsis. Voltage-clamp results demonstrated that SLAC1 inhibited KAT1 dramatically, but did not inhibit KAT2. SLAH3 inhibited KAT1 to a weaker degree relative to SLAC1. Both the N terminus and the C terminuses of SLAC1 inhibited KAT1, but the inhibition by the N terminus was stronger. The C terminus was essential for the inhibition of KAT1 by SLAC1. Furthermore, drought stress strongly up-regulated the expression of SLAC1 and SLAH3 in Arabidopsis guard cells, and the over-expression of wild type and truncated SLAC1 dramatically impaired K+in currents of guard cells and light-induced stomatal opening. Additionally, the inhibition of KAT1 by SLAC1 and KC1 only partially overlapped, suggesting that SLAC1 and KC1 inhibited K+in channels using different molecular mechanisms. Taken together, we discovered a novel regulatory mechanism for stomatal movement, in which singling pathways for stomatal closure and opening are directly coupled together by protein-protein interaction between SLAC1/SLAH3 and KAT1 in Arabidopsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.