ArticleBirth defects research. Part A, Clinical and molecular teratology2016
Maternal exposure to radiographic exams and major structural birth defects.
Article in Birth defects research. Part A, Clinical and molecular teratology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 8 citations in OpenAlex.
- Neurocritical Care of the Pregnant Patient.Current treatment options in neurology · 2021Review
- Risk of congenital heart disease due to exposure to common electrical appliances during early pregnancy: a case-control study.Environmental science and pollution research international · 2021Article
- Residential radon and birth defects: A population-based assessment.Birth defects research. Part A, Clinical and molecular teratology · 2016Article
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8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAn increasing number of radiologic exams are performed in the United States, but very few studies have examined the effects of maternal exposure to radiologic exams during the periconceptional period and birth defects.
objectivesTo assess the association between maternal exposure to radiologic exams during the periconceptional period and 19 categories of birth defects using a large population-based study of birth defects.
methodsWe studied 27,809 case mothers and 10,200 control mothers who participated in the National Birth Defects Prevention Study and delivered between 1997 and 2009. Maternal exposure to radiologic exams that delivered ionizing radiation to the urinary tract, lumbar spine, abdomen, or pelvis were identified based on the mother's report of type of radiologic exams, organ or body part scanned and the month during which the exam occurred
resultsOverall, 0.9% of mothers reported exposure to one of these types of radiographic exams during the periconceptional period. We observed significant associations between maternal exposure during the first trimester and isolated Dandy-Walker malformation (odds ratio = 7.7; 95% confidence interval, 1.8-33) and isolated d-transposition of the great arteries (odds ratio = 3.8; 95% confidence interval, 1.4-10.3). However, the result for isolated Dandy-Walker malformation was based on only two exposed cases.
conclusionThese results should be interpreted cautiously because multiple statistical tests were conducted and measurements of exposure were based on maternal report. However, our results may be useful for generating hypotheses for future studies. Birth Defects Research (Part A) 106:563-572, 2016. © 2016 Wiley Periodicals, Inc.
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