ArticleProceedings of the National Academy of Sciences of the United States of America2016
Epigenome confrontation triggers immediate reprogramming of DNA methylation and transposon silencing in Arabidopsis thaliana F1 epihybrids.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51 citing papers in PubMed, 96 citations in OpenAlex.
- Multi-Omics and Liquid Biopsy Integration for Precision Stratification of Breast Cancer.Cancers · 2026Review
- Inheritance of DNA Methylation Patterns and Its Role in Modulating Allelic Expression inPlants (Basel, Switzerland) · 2025Article
- Long-read detection of transposable element mobilization in the soma of hypomethylated Arabidopsis thaliana individuals.Genome biology · 2025Article
- Recent advances in the use of plant growth promoting microorganisms for enhancing micropropagation efficiency.Frontiers in plant science · 2025Review
- Mapping parental DMRs predictive of local and distal methylome remodeling in epigenetic F1 hybrids.Life science alliance · 2024Article
- DNA methylation: an emerging paradigm of gene regulation under drought stress in plants.Molecular biology reports · 2024Review
- The Genomic Shock Hypothesis: Genetic and Epigenetic Alterations of Transposable Elements after Interspecific Hybridization in Plants.Epigenomes · 2023Review
- A review of plant epigenetics through the lens of almond.The plant genome · 2023Review
- RTEL1 is required for silencing and epigenome stability.Nucleic acids research · 2023Article
- Warmer temperature during asexual reproduction induce methylome, transcriptomic, and lasting phenotypic changes inHorticulture research · 2023Article
- Single-molecule targeted accessibility and methylation sequencing of centromeres, telomeres and rDNAs in Arabidopsis.Nature plants · 2023Article
- Arms race between anti-silencing and RdDM in noncoding regions of transposable elements.EMBO reports · 2023Article
- Epigenomics in stress tolerance of plants under the climate change.Molecular biology reports · 2023Review
- Subgenome evolutionary dynamics in allotetraploid ferns: insights from the gene expression patterns in the allotetraploid speciesFrontiers in plant science · 2023Article
- Exploitation of epigenetic variation of crop wild relatives for crop improvement and agrobiodiversity preservation.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Review
- Fast co-evolution of anti-silencing systems shapes the invasiveness of Mu-like DNA transposons in eudicots.The EMBO journal · 2022Article
- Review
- Local and global crosstalk among heterochromatin marks drives DNA methylome patterning in Arabidopsis.Nature communications · 2022Article
- Heterochromatin is a quantitative trait associated with spontaneous epiallele formation.Nature communications · 2021Article
- The genetic and epigenetic landscape of theScience (New York, N.Y.) · 2021Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genes and transposons can exist in variable DNA methylation states, with potentially differential transcription. How these epialleles emerge is poorly understood. Here, we show that crossing an Arabidopsis thaliana plant with a hypomethylated genome and a normally methylated WT individual results, already in the F1 generation, in widespread changes in DNA methylation and transcription patterns. Novel nonparental and heritable epialleles arise at many genic loci, including a locus that itself controls DNA methylation patterns, but with most of the changes affecting pericentromeric transposons. Although a subset of transposons show immediate resilencing, a large number display decreased DNA methylation, which is associated with de novo or enhanced transcriptional activation and can translate into transposon mobilization in the progeny. Our findings reveal that the combination of distinct epigenomes can be viewed as an epigenomic shock, which is characterized by a round of epigenetic variation creating novel patterns of gene and TE regulation.
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