ArticleProceedings of the National Academy of Sciences of the United States of America2016
Neural basis of reward anticipation and its genetic determinants.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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31citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 7% of its field
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
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- Brain imaging genetics in ADHD and beyond - Mapping pathways from gene to disorder at different levels of complexity.Neuroscience and biobehavioral reviews · 2017Pooled it
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- Neurocognitive characterization of behaviour and mental illness through time-varying brain network analysis.Nature communications · 2026Article
- Reimagining the biopsychosocial model: hierarchical mechanisms from transdiagnostic to precision psychiatry.Journal of psychiatry & neuroscience : JPN · 2026Review
- Bitter Sensing ProtectsThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- DNAJC13 influences responses of the extended reward system to conditioned stimuli: a genome-wide association study.European archives of psychiatry and clinical neuroscience · 2025Article
- How Distributed Subcortical Integration of Reward and Threat May Inform Subsequent Approach-Avoidance Decisions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Screen time, brain network development and socio-emotional competence in childhood: moderation of associations by parent-child reading.Psychological medicine · 2024Article
- Identification of a Composite Latent Dimension of Reward and Impulsivity Across Clinical, Behavioral, and Neurobiological Domains Among Youth.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- The effect of reward expectation on working memory of emotional faces under different levels of cognitive load: an ERP study.Experimental brain research · 2024Article
- The Role of Thermodynamic and Informational Entropy in Improving Real Estate Valuation Methods.Entropy (Basel, Switzerland) · 2023Article
- Understanding Anhedonia from a Genomic Perspective.Current topics in behavioral neurosciences · 2022Review
- Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases.Nature communications · 2021Article
- The longitudinal stability of fMRI activation during reward processing in adolescents and young adults.NeuroImage · 2021Article
- Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence.Molecular psychiatry · 2021Article
- [IMAGEN and beyond: novel population neuroscientific strategies for clinical and global cohorts in the STRATIFY and GIGA consortia].Der Nervenarzt · 2021Review
- [The IMAGEN cohort: perspectives and problems of longitudinal research].Der Nervenarzt · 2021Review
- Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse.Science advances · 2021Article
- Neural Biomarkers Distinguish Severe From Mild Autism Spectrum Disorder Among High-Functioning Individuals.Frontiers in human neuroscience · 2021Article
Corrections and comments
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Authors and funding
36 authors at 17 institutions in 7 countries.
Tianye JiaInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom; Medical Research Council Social, Genetic and Developmental Psychiatry Centre, London SE5 8AF, United Kingdom;
Christine MacareInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom; Medical Research Council Social, Genetic and Developmental Psychiatry Centre, London SE5 8AF, United Kingdom;
Sylvane DesrivièresInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom; Medical Research Council Social, Genetic and Developmental Psychiatry Centre, London SE5 8AF, United Kingdom;
Dante A GonzalezDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390;
Chenyang TaoCenter for Computational Systems Biology, Fudan University, Shanghai 200433, People's Republic of China;
Xiaoxi JiCenter for Computational Systems Biology, Fudan University, Shanghai 200433, People's Republic of China;
Barbara RuggeriInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom; Medical Research Council Social, Genetic and Developmental Psychiatry Centre, London SE5 8AF, United Kingdom;
Frauke NeesDepartment of Child and Adolescent Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Heidelberg, Germany; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159 Heidelberg, Germany;
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Heidelberg, Germany;
Gareth J BarkerInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom;
Arun L W BokdeTrinity College Institute of Neuroscience and Discipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin 2, Ireland;
Uli BrombergDepartment of System Neuroscience, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany;
Christian BüchelDepartment of System Neuroscience, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany;
Patricia J ConrodInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom; Department of Psychiatry, Université de Montréal, Centre Hospitalier Universitaire Ste Justine Hospital, Montréal, QC, Canada H3T 1C5;
Rachel DoveDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390;
Vincent FrouinNeurospin, Commissariat à l'Energie Atomique et aux Energies Alternatives, 91190 Paris, France;ORCID http://orcid.org/0000-0001-9360-6623
Jürgen GallinatClinic for Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany;
Hugh GaravanDepartments of Psychiatry and Psychology, University of Vermont, Burlington, VT 05401; Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland;
Penny A GowlandSchool of Physics and Astronomy, University of Nottingham, Nottingham NG7 2RD, United Kingdom;
Andreas HeinzClinic for Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany;
Bernd IttermannPhysikalisch-Technische Bundesanstalt, Braunschweig und Berlin, D-10587 Medizinische Messtechnik, Germany;
Mark LathropMcGill University and Genome Quebec Innovation Centre, Montréal, QC, Canada H3A 0G1;
Hervé LemaitreINSERM Commissariat à l'énergie atomique et aux énergies alternatives Unit 1000 "Imaging & Psychiatry," University Paris Sud, 91401 Orsay, France;
Jean-Luc MartinotINSERM Commissariat à l'énergie atomique et aux énergies alternatives Unit 1000 "Imaging & Psychiatry," University Paris Sud, 91401 Orsay, France;
Tomáš PausRotman Research Institute, University of Toronto, Toronto, ON, Canada M6A 2E1; School of Psychology, University of Nottingham, Nottingham NG7 2RD, United Kingdom; Montreal Neurological Institute, McGill University, Montréal, QC, Canada H3A 2B4;
Zdenka PausovaThe Hospital for Sick Children, University of Toronto, Toronto, ON, Canada M5G 1X8;
Jean-Baptiste PolineNeurospin, Commissariat à l'Energie Atomique et aux Energies Alternatives, 91190 Paris, France; Henry H. Wheeler, Jr. Brain Imaging Center, University of California, Berkeley, CA 94720;
Marcella RietschelDepartment of Child and Adolescent Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Heidelberg, Germany; Department of Genetic Epidemiology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159 Heidelberg, Germany;
Trevor RobbinsBehavioural and Clinical Neurosciences Institute, Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom;
Michael N SmolkaDepartment of Psychiatry and Psychotherapy, and Neuroimaging Center, Technische Universität Dresden, 01187 Dresden, Germany;ORCID http://orcid.org/0000-0001-5398-5569
Christian P MüllerDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nuremberg, 91054 Erlangen, Germany;
Jianfeng FengCenter for Computational Systems Biology, Fudan University, Shanghai 200433, People's Republic of China; Department of Mathematics, Warwick University, Coventry CV4 7AL, United Kingdom.
Adrian RothenfluhDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390;
Herta FlorDepartment of Child and Adolescent Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Heidelberg, Germany; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159 Heidelberg, Germany;
Gunter SchumannInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom; Medical Research Council Social, Genetic and Developmental Psychiatry Centre, London SE5 8AF, United Kingdom; gunter.schumann@kcl.ac.uk.
IMAGEN Consortium
King's College London · GBUniversität Hamburg · DEHeidelberg University · DECommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRInserm · FRFudan University · CNThe University of Texas Southwestern Medical Center · USMcGill University and Génome Québec Innovation Centre · CAMontreal Neurological Institute and Hospital · CAPhysikalisch-Technische Bundesanstalt · DETechnische Universität Dresden · DETrinity College Dublin · IEUniversity of Cambridge · GBUniversity of Nottingham · GBUniversity of Toronto · CAUniversity of Vermont · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DE
Funding
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MTraining Program in Neurodevelopmental DisabilitiesT32NS007413 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI AMELIA J EISCH, ERIC D MARSH · 1998 to 2026
$8.9MBasic Science Training Program in Drug Abuse ResearchT32DA007290 · NIDA · YALE UNIVERSITY · PI SELF, DAVID W · 1992 to 2017
$6.7MControl of Alcohol Responses by Actin-Regulating GenesR01AA019526 · NIAAA · UT SOUTHWESTERN MEDICAL CENTER · PI ROTHENFLUH, ADRIAN · 2010 to 2025
$5.4MAxon, Testosterone and Mental Health during AdolescenceR01MH085772 · NIMH · BAYCREST CENTRE FOR GERIATRIC CARE · PI PAUS, TOMAS · 2010 to 2014
$1.5MRole of histone demethylases in experience dependent alcohol behaviorR21AA022404 · NIAAA · UT SOUTHWESTERN MEDICAL CENTER · PI BUSZCZAK, MICHAEL · 2014 to 2015
$411kMedical Research Council 93558Medical Research Council G0901858Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MR/N000390/1NIAAA NIH HHS R01 AA019526NIAAA NIH HHS R21 AA022404NIBIB NIH HHS U54 EB020403NIDA NIH HHS T32 DA007290NIMH NIH HHS R01 MH085772NINDS NIH HHS T32 NS007413Wellcome Trust 102215
Abstract
Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity during reward anticipation. We examined brain nodes engaged by reward anticipation in 1,544 adolescents and identified a network containing a core striatal node and cortical nodes facilitating outcome prediction and response preparation. Distinct nodes and functional connections were preferentially associated with either adolescent hyperactivity or alcohol consumption, thus conveying specificity of reward processing to clinically relevant behavior. We observed associations between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila Our data provide a neurobehavioral model explaining the heterogeneity of reward-related behaviors and generate a hypothesis accounting for their enduring nature.
Indexed as
Brain MappingRewardAdolescentAlcohol DrinkingAnimalsAnticipation, PsychologicalATPases Associated with Diverse Cellular ActivitiesAttention Deficit Disorder with HyperactivityChildCorpus StriatumDrosophilaEndosomal Sorting Complexes Required for TransportFemaleForecastingGenome-Wide Association StudyHaplotypesATPases Associated with Diverse Cellular ActivitiesEndosomal Sorting Complexes Required for TransportVacuolar Proton-Translocating ATPasesVPS4A protein, humandopamine receptorfMRIGWASneural networkVPS4A
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