Evidence map›Paper›PMID 27001821›Full record

ArticleAntimicrobial agents and chemotherapy2016

Advanced Molecular Detection of Malarone Resistance.

Eldin Talundzic, Mateusz M Plucinski, Shweta Biliya, Luciana M Silva-Flannery, Paul M Arguin, Eric S Halsey, John W Barnwell, Fredrik Vannberg, Venkatachalam Udhayakumar

Abstract readCase Reports
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Selection of CytochromeAntimicrobial agents and chemotherapy · 2021
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Emergence and Spread ofAntimicrobial agents and chemotherapy · 2018
    Article
  11. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eldin TalundzicMalaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA Atlanta Research and Education Foundation, Veterans Affairs Medical Center, Atlanta, Georgia, USA etalundzic@cdc.gov.
Mateusz M PlucinskiMalaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA President's Malaria Initiative, Atlanta, Georgia, USA.
Shweta BiliyaSchool of Biology, Georgia Institute of Technology, Atlanta, Georgia, USA.
Luciana M Silva-FlanneryMalaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA Atlanta Research and Education Foundation, Veterans Affairs Medical Center, Atlanta, Georgia, USA.
Paul M ArguinMalaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Eric S HalseyMalaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA President's Malaria Initiative, Atlanta, Georgia, USA.
John W BarnwellMalaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Fredrik VannbergSchool of Biology, Georgia Institute of Technology, Atlanta, Georgia, USA.
Venkatachalam UdhayakumarMalaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rapid emergence of drug-resistant malaria parasites during the course of an infection remains a major challenge for providing accurate treatment guidelines. This is particularly important in cases of malaria treatment failure. Using a previously well-characterized case of malaria treatment failure, we show the utility of using next-generation sequencing for early detection of the rise and selection of a previously reported atovaquone-proguanil (malarone) drug resistance-associated mutation.

Indexed as

MutationAdultAntimalarialsAtovaquoneCytochromes bDrug CombinationsDrug ResistanceGene ExpressionHigh-Throughput Nucleotide SequencingHumansMalaria, FalciparumMaleNigeriaPlasmodium falciparumProguanilProtozoan ProteinsAntimalarialsAtovaquoneatovaquone, proguanil drug combinationCytochromes bDrug CombinationsProguanilProtozoan Proteins

Identifiers

PMID27001821
PMCPMC4879379

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.